Seroatlas · Human Serome Atlas

EOLA2

Protein EOLA2

Also known as: CXorf40B, EOLA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DE9
Gene
EOLA2
Ensembl
ENSG00000197021
Chromosome
X
Canonical length
158 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>Q96DE9|EOLA2
     1  MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG DACRELLVER
    61  LGMTPAQIQA LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT PDEVVELENQ AALTNLKQKY
   121  LTVISNPRWL LEPIPRKGGK DVFQVDIPEH LIPLGHEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EOLA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 80 nTPM
  • bone marrow: 57 nTPM
  • ovary: 41 nTPM
  • liver: 40 nTPM
  • pancreas: 39 nTPM
  • pituitary gland: 37 nTPM

Single-cell type

  • syncytiotrophoblasts: 104 nCPM
  • cytotrophoblasts: 61 nCPM
  • oocytes: 51 nCPM
  • granulosa cells: 43 nCPM
  • migrating cytotrophoblasts: 40 nCPM
  • ovarian stromal cells: 31 nCPM

Immune cell

  • NK-cell: 59 nTPM
  • basophil: 39 nTPM
  • plasmacytoid DC: 37 nTPM
  • T-reg: 37 nTPM
  • eosinophil: 36 nTPM
  • gdT-cell: 36 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 21 nTPM
  • midbrain: 20 nTPM
  • basal ganglia: 20 nTPM
  • hippocampal formation: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0.02
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EOLA2 as an antibody target. Whether an autoantibody or antibody against EOLA2 could matter depends on whether native EOLA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EOLA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EOLA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EOLA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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