Seroatlas · Human Serome Atlas

EOLA1

Protein EOLA1

Also known as: CXorf40, CXorf40A, EOLA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TE69
Gene: EOLA1
Ensembl: ENSG00000197620
Chromosome: X
Canonical length: 158 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in regulation of interleukin-6 production. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>Q8TE69|EOLA1
     1  MKFGCLSFRQ PYAGFVLNGI KTVETRWRPL LSSQRNCTIA VHIAHRDWEG DAWRELLVER
    61  LGMTPAQIQA LLRKGEKFGR GVIAGLVDIG ETLQCPEDLT PDEVVELENQ AVLTNLKQKY
   121  LTVISNPRWL LEPIPRKGGK DVFQVDIPEH LIPLGHEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EOLA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 58 nTPM
parathyroid gland: 36 nTPM
pituitary gland: 33 nTPM
skeletal muscle: 30 nTPM
epididymis: 30 nTPM
heart muscle: 30 nTPM

Single-cell type

cardiomyocytes: 103 nCPM
syncytiotrophoblasts: 84 nCPM
epicardial cells: 48 nCPM
cytotrophoblasts: 34 nCPM
oocytes: 23 nCPM
parietal cells: 23 nCPM

Immune cell

plasmacytoid DC: 42 nTPM
NK-cell: 35 nTPM
basophil: 32 nTPM
T-reg: 22 nTPM
gdT-cell: 22 nTPM
naive CD4 T-cell: 20 nTPM

Brain region

choroid plexus: 27 nTPM
hippocampal formation: 26 nTPM
cerebral cortex: 24 nTPM
white matter: 23 nTPM
midbrain: 22 nTPM
cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0.59
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of EOLA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MT2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EOLA1 as an antibody target. Whether an autoantibody or antibody against EOLA1 could matter depends on whether native EOLA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EOLA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EOLA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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