Seroatlas · Human Serome Atlas

ENTREP3

Protein ENTREP3

Also known as: C1orf2, cote1, EREP3_HUMAN, FAM189B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P81408
Gene
ENTREP3
Ensembl
ENSG00000160767
Chromosome
1
Canonical length
668 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

668 residues, UniProt reviewed canonical sequence.

>P81408|ENTREP3
     1  MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLV QVLLGILVVT FSMVASSVTT
    61  TESIKRSCPS WAGFSLAFSG VVGIVSWKRP FTLVISFFSL LSVLCVMLSM AGSVLSCKNA
   121  QLARDFQQCS LEGKVCVCCP SVPLLRPCPE SGQELKVAPN STCDEARGAL KNLLFSVCGL
   181  TICAAIICTL SAIVCCIQIF SLDLVHTLAP ERSVSGPLGP LGCTSPPPAP LLHTMLDLEE
   241  FVPPVPPPPY YPPEYTCSSE TDAQSITYNG SMDSPVPLYP TDCPPSYEAV MGLRGDSQAT
   301  LFDPQLHDGS CICERVASIV DVSMDSGSLV LSAIGDLPGG SSPSEDSCLL ELQGSVRSVD
   361  YVLFRSIQRS RAGYCLSLDC GLRGPFEESP LPRRPPRAAR SYSCSAPEAP PPLGAPTAAR
   421  SCHRLEGWPP WVGPCFPELR RRVPRGGGRP AAAPPTRAPT RRFSDSSGSL TPPGHRPPHP
   481  ASPPPLLLPR SHSDPGITTS SDTADFRDLY TKVLEEEAAS VSSADTGLCS EACLFRLARC
   541  PSPKLLRARS AEKRRPVPTF QKVPLPSGPA PAHSLGDLKG SWPGRGLVTR FLQISRKAPD
   601  PSGTGAHGHK QVPRSLWGRP GRESLHLRSC GDLSSSSSLR RLLSGRRLER GTRPHSLSLN
   661  GGSRETGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTREP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 24 nTPM
  • colon: 19 nTPM
  • urinary bladder: 18 nTPM
  • cerebellum: 18 nTPM
  • cerebral cortex: 17 nTPM
  • blood vessel: 16 nTPM

Single-cell type

  • brain excitatory neurons: 17 nCPM
  • other brain neurons: 17 nCPM
  • brain inhibitory neurons: 15 nCPM
  • oligodendrocyte progenitor cells: 12 nCPM
  • bergmann glia: 11 nCPM
  • astrocytes: 9.8 nCPM

Immune cell

  • NK-cell: 2.1 nTPM
  • MAIT T-cell: 0.6 nTPM
  • classical monocyte: 0.4 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • myeloid DC: 0.3 nTPM

Brain region

  • pons: 43 nTPM
  • thalamus: 41 nTPM
  • cerebral cortex: 40 nTPM
  • medulla oblongata: 36 nTPM
  • amygdala: 25 nTPM
  • cerebellum: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTREP3 as an antibody target. Whether an autoantibody or antibody against ENTREP3 could matter depends on whether native ENTREP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTREP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENTREP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENTREP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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