Seroatlas · Human Serome Atlas

ENTREP2

Protein ENTREP2

Also known as: EREP2_HUMAN, FAM189A1, KIAA0574, TMEM228

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60320
Gene: ENTREP2
Ensembl: ENSG00000104059
Chromosome: 15
Canonical length: 539 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Vesicles,Aggresome

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>O60320|ENTREP2
     1  MPPAGGPRAP RPAALPRSLS RLRECPGRSR IVLALGATQM ALGCLIVAVS FAALALTTSA
    61  RVRHSCPFWA GFSVLLSGLI GVVSWKRPLS LVITFFMLLS AVCVMLNLAG SILSCQNAQL
   121  VNSLEGCQLI KFDSVEVCVC CELQHQSSGC SNLGETLKLN PLQENCNAVR LTLKDLLFSV
   181  CALNVLSTIV CALATAMCCM QMVSSDVLQM FLPQRSHPAN PTCVTPHGTV LHQTLDFDEF
   241  IPPLPPPPYY PPEYTCTPST EAQRGLHLDF APSPFGTLYD VAINSPGLLY PAELPPPYEA
   301  VVGQPPASQV TSIGQQVAES SSGDPNTSAG FSTPVPADST SLLVSEGTAT PGSSPSPDGP
   361  VGAPAPSEPA LPPGHVSPED PGMGSQVQPG PGRVSRSTSD PTLCTSSMAG DASSHRPSCS
   421  QDLEAGLSEA VPGSASMSRS ATAACRAQLS PAGDPDTWKT DQRPTPEPFP ATSKERPRSL
   481  VDSKAYADAR VLVAKFLEHS HCALPTEAQH MVGAMRLAVT NEERLEEEAV FGADVLDQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTREP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 23 nTPM
amygdala: 17 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 9 nTPM
cerebellum: 5.8 nTPM
hypothalamus: 5.8 nTPM

Single-cell type

choroid plexus epithelial cells: 312 nCPM
brain excitatory neurons: 193 nCPM
proximal tubule cells: 163 nCPM
brain inhibitory neurons: 150 nCPM
other brain neurons: 135 nCPM
distal convoluted tubule cells: 126 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 7.1 nTPM
amygdala: 6.1 nTPM
cerebral cortex: 6.1 nTPM
basal ganglia: 5.8 nTPM
thalamus: 4.1 nTPM
white matter: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.04
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTREP2 as an antibody target. Whether an autoantibody or antibody against ENTREP2 could matter depends on whether native ENTREP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTREP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENTREP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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