Seroatlas · Human Serome Atlas

ENTPD7

Ectonucleoside triphosphate diphosphohydrolase 7

Also known as: ENTP7_HUMAN, FLJ30978, LALP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQZ7
Gene: ENTPD7
Ensembl: ENSG00000198018
Chromosome: 10
Canonical length: 604 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

604 residues, UniProt reviewed canonical sequence.

>Q9NQZ7|ENTPD7
     1  MARISFSYLC PASWYFTVPT VSPFLRQRVA FLGLFFISCL LLLMLIIDFR HWSASLPRDR
    61  QYERYLARVG ELEATDTEDP NLNYGLVVDC GSSGSRIFVY FWPRHNGNPH DLLDIKQMRD
   121  RNSQPVVKKI KPGISAMADT PEHASDYLRP LLSFAAAHVP VKKHKETPLY ILCTAGMRLL
   181  PERKQLAILA DLVKDLPLEF DFLFSQSQAE VISGKQEGVY AWIGINFVLG RFDHEDESDA
   241  EATQELAAGR RRTVGILDMG GASLQIAYEV PTSTSVLPAK QEEAAKILLA EFNLGCDVQH
   301  TEHVYRVYVT TFLGFGGNFA RQRYEDLVLN ETLNKNRLLG QKTGLSPDNP FLDPCLPVGL
   361  TDVVERNSQV LHVRGRGDWV SCGAMLSPLL ARSNTSQASL NGIYQSPIDF NNSEFYGFSE
   421  FFYCTEDVLR IGGRYHGPTF AKAAQDYCGM AWSVLTQRFK NGLFSSHADE HRLKYQCFKS
   481  AWMYQVLHEG FHFPYDYPNL RTAQLVYDRE VQWTLGAILY KTRFLPLRDL RQEGVRQAHG
   541  SWFRLSFVYN HYLFFACILV VLLAIFLYLL RLRRIHHRQT RASAPLDLLW LEEVVPMMGV
   601  QVGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTPD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

duodenum: 14 nTPM
small intestine: 14 nTPM
urinary bladder: 9.5 nTPM
bone marrow: 6.6 nTPM
pancreas: 6.5 nTPM
placenta: 6.1 nTPM

Single-cell type

urothelial cells: 194 nCPM
ocular epithelial cells: 120 nCPM
enterocytes: 93 nCPM
epididymal basal cells: 75 nCPM
endometrial secretory cells: 68 nCPM
neutrophil progenitors: 51 nCPM

Immune cell

plasmacytoid DC: 2.3 nTPM
myeloid DC: 1.3 nTPM
eosinophil: 0.9 nTPM
intermediate monocyte: 0.8 nTPM
NK-cell: 0.8 nTPM
classical monocyte: 0.6 nTPM

Brain region

choroid plexus: 12 nTPM
cerebellum: 7.3 nTPM
hippocampal formation: 5.4 nTPM
cerebral cortex: 5.2 nTPM
midbrain: 4.9 nTPM
basal ganglia: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

CTP metabolic process
GTP metabolic process
nucleobase-containing small molecule catabolic process
regulation of immune response
T-helper 17 cell differentiation
UDP catabolic process
CTP catabolic process
UTP catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTPD7 as an antibody target. Whether an autoantibody or antibody against ENTPD7 could matter depends on whether native ENTPD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTPD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENTPD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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