Seroatlas · Human Serome Atlas

ENTPD5

Nucleoside diphosphate phosphatase ENTPD5

Also known as: CD39L4, ENTP5_HUMAN, NTPDase-5, PCPH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75356
Gene: ENTPD5
Ensembl: ENSG00000187097
Chromosome: 14
Canonical length: 428 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>O75356|ENTPD5
     1  MATSWGTVFF MLVVSCVCSA VSHRNQQTWF EGIFLSSMCP INVSASTLYG IMFDAGSTGT
    61  RIHVYTFVQK MPGQLPILEG EVFDSVKPGL SAFVDQPKQG AETVQGLLEV AKDSIPRSHW
   121  KKTPVVLKAT AGLRLLPEHK AKALLFEVKE IFRKSPFLVP KGSVSIMDGS DEGILAWVTV
   181  NFLTGQLHGH RQETVGTLDL GGASTQITFL PQFEKTLEQT PRGYLTSFEM FNSTYKLYTH
   241  SYLGFGLKAA RLATLGALET EGTDGHTFRS ACLPRWLEAE WIFGGVKYQY GGNQEGEVGF
   301  EPCYAEVLRV VRGKLHQPEE VQRGSFYAFS YYYDRAVDTD MIDYEKGGIL KVEDFERKAR
   361  EVCDNLENFT SGSPFLCMDL SYITALLKDG FGFADSTVLQ LTKKVNNIET GWALGATFHL
   421  LQSLGISH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTPD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 247 nTPM

Expression across tissuesHPA

Tissue

liver: 247 nTPM
rectum: 101 nTPM
kidney: 89 nTPM
colon: 89 nTPM
duodenum: 68 nTPM
small intestine: 64 nTPM

Single-cell type

prostatic club cells: 253 nCPM
colonocytes: 188 nCPM
hepatocytes: 164 nCPM
prostatic glandular cells: 142 nCPM
goblet cells: 127 nCPM
proximal tubule cells: 114 nCPM

Immune cell

basophil: 18 nTPM
eosinophil: 9.4 nTPM
gdT-cell: 2.6 nTPM
intermediate monocyte: 2.3 nTPM
naive CD4 T-cell: 2.1 nTPM
naive CD8 T-cell: 2.1 nTPM

Brain region

white matter: 21 nTPM
medulla oblongata: 19 nTPM
midbrain: 18 nTPM
choroid plexus: 18 nTPM
thalamus: 18 nTPM
basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTPD5 as an antibody target. Whether an autoantibody or antibody against ENTPD5 could matter depends on whether native ENTPD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTPD5 is annotated as secreted, so native ENTPD5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ENTPD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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