Seroatlas · Human Serome Atlas

ENTPD3

Ectonucleoside triphosphate diphosphohydrolase 3

Also known as: CD39L3, ENTP3_HUMAN, HB6, NTPDase-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75355
Gene: ENTPD3
Ensembl: ENSG00000168032
Chromosome: 3
Canonical length: 529 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>O75355|ENTPD3
     1  MFTVLTRQPC EQAGLKALYR TPTIIALVVL LVSIVVLVSI TVIQIHKQEV LPPGLKYGIV
    61  LDAGSSRTTV YVYQWPAEKE NNTGVVSQTF KCSVKGSGIS SYGNNPQDVP RAFEECMQKV
   121  KGQVPSHLHG STPIHLGATA GMRLLRLQNE TAANEVLESI QSYFKSQPFD FRGAQIISGQ
   181  EEGVYGWITA NYLMGNFLEK NLWHMWVHPH GVETTGALDL GGASTQISFV AGEKMDLNTS
   241  DIMQVSLYGY VYTLYTHSFQ CYGRNEAEKK FLAMLLQNSP TKNHLTNPCY PRDYSISFTM
   301  GHVFDSLCTV DQRPESYNPN DVITFEGTGD PSLCKEKVAS IFDFKACHDQ ETCSFDGVYQ
   361  PKIKGPFVAF AGFYYTASAL NLSGSFSLDT FNSSTWNFCS QNWSQLPLLL PKFDEVYARS
   421  YCFSANYIYH LFVNGYKFTE ETWPQIHFEK EVGNSSIAWS LGYMLSLTNQ IPAESPLIRL
   481  PIEPPVFVGT LAFFTAAALL CLAFLAYLCS ATRRKRHSEH AFDHAVDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTPD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 23 nTPM
salivary gland: 21 nTPM
cervix: 20 nTPM
pancreas: 15 nTPM
urinary bladder: 12 nTPM
cerebral cortex: 8.3 nTPM

Single-cell type

urothelial cells: 133 nCPM
brain inhibitory neurons: 114 nCPM
breast lactating cells: 93 nCPM
cardiomyocytes: 89 nCPM
retinal ganglion cells: 77 nCPM
endometrial glandular cells: 58 nCPM

Immune cell

plasmacytoid DC: 3.5 nTPM
basophil: 0.5 nTPM
NK-cell: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

basal ganglia: 49 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 19 nTPM
pons: 19 nTPM
hypothalamus: 17 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTPD3 as an antibody target. Whether an autoantibody or antibody against ENTPD3 could matter depends on whether native ENTPD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTPD3 is annotated at the cell surface, where native ENTPD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENTPD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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