Seroatlas · Human Serome Atlas

ENTPD2

Ectonucleoside triphosphate diphosphohydrolase 2

Also known as: CD39L1, ENTP2_HUMAN, NTPDase-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5L3
Gene
ENTPD2
Ensembl
ENSG00000054179
Chromosome
9
Canonical length
495 aa
Protein class
Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q9Y5L3|ENTPD2
     1  MAGKVRSLLP PLLLAAAGLA GLLLLCVPTR DVREPPALKY GIVLDAGSSH TSMFIYKWPA
    61  DKENDTGIVG QHSSCDVPGG GISSYADNPS GASQSLVGCL EQALQDVPKE RHAGTPLYLG
   121  ATAGMRLLNL TNPEASTSVL MAVTHTLTQY PFDFRGARIL SGQEEGVFGW VTANYLLENF
   181  IKYGWVGRWF RPRKGTLGAM DLGGASTQIT FETTSPAEDR ASEVQLHLYG QHYRVYTHSF
   241  LCYGRDQVLQ RLLASALQTH GFHPCWPRGF STQVLLGDVY QSPCTMAQRP QNFNSSARVS
   301  LSGSSDPHLC RDLVSGLFSF SSCPFSRCSF NGVFQPPVAG NFVAFSAFFY TVDFLRTSMG
   361  LPVATLQQLE AAAVNVCNQT WAQLQARVPG QRARLADYCA GAMFVQQLLS RGYGFDERAF
   421  GGVIFQKKAA DTAVGWALGY MLNLTNLIPA DPPGLRKGTD FSSWVVLLLL FASALLAALV
   481  LLLRQVHSAK LPSTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTPD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 12 nTPM
  • skin: 9.7 nTPM
  • amygdala: 9.3 nTPM
  • basal ganglia: 8.6 nTPM
  • cerebral cortex: 8.2 nTPM
  • hypothalamus: 8 nTPM

Single-cell type

  • leydig cells: 204 nCPM
  • peritubular myoid cells: 99 nCPM
  • ependymal cells: 78 nCPM
  • schwann cells: 63 nCPM
  • enterocytes: 56 nCPM
  • astrocytes: 44 nCPM

Immune cell

  • eosinophil: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 65 nTPM
  • hypothalamus: 57 nTPM
  • thalamus: 53 nTPM
  • amygdala: 33 nTPM
  • medulla oblongata: 33 nTPM
  • spinal cord: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ENTPD2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0
gnomAD missense Z
-0.66
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTPD2 as an antibody target. Whether an autoantibody or antibody against ENTPD2 could matter depends on whether native ENTPD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTPD2 is annotated at the cell surface, where native ENTPD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENTPD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENTPD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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