Seroatlas · Human Serome Atlas

ENTHD1

ENTH domain-containing protein 1

Also known as: ENTD1_HUMAN, FLJ25421

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYW4
Gene
ENTHD1
Ensembl
ENSG00000176177
Chromosome
22
Canonical length
607 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>Q8IYW4|ENTHD1
     1  MAFRRQVKNF VKNYSDAEIK VREATSNDPW GPSSSLMLDI SDLTFNTISL SEIMNMLWHR
    61  LNDHGKNWRH VYKSLTLMDY LIKNGSKKVI QHCREGFCNL QTLKDFQHID EAGKDQGYYI
   121  REKSKQVITL LMDEPLLCKE REVACRTRQR TSHSILFSKR QLGSSNSLTA CTSAPTPDIS
   181  ASEKKYKLPK FGRLHNKRNV CKAGLKQEHC QDVHLPTETM LSQETLPLKI HGWKSTEDLM
   241  TFLDDDPELP LLATPPSIVS PITCLSEAEE VCNLSGADAV PTLSENSPSG QRDVSLDKRS
   301  DGIFTNTVTE NLLETPLEKQ SAAEGLKTLT ILPACWSSKE EFISPDLRVS KSDSTFHNQA
   361  SVETLCLSPS FKIFDRVKEI VINKAYQKPA QSSIQMDDKI LKTTTRVSTA SEGASSFSPL
   421  SMSSPDLASP EKSAHLLSPI LAGPSFWTLS HQQLSSTSFK DEDKTAKLHH SFASRGPVSS
   481  DVEENDSLNL LGILPNNSDS AKKNISHISS SHWGEFSTQN VDQFIPLSCS GFQSTKDFPQ
   541  EPEAKNSISV LLREVKRAIA RLHEDLSTVI QELNVINNIL MSMSLNSSQI SQSSQVPQSS
   601  EGSSDQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • thymus: 1.2 nTPM
  • basal ganglia: 0.9 nTPM
  • lymph node: 0.6 nTPM
  • tonsil: 0.5 nTPM
  • appendix: 0.3 nTPM

Single-cell type

  • cardiomyocytes: 227 nCPM
  • early primary spermatocytes: 125 nCPM
  • sertoli cells: 53 nCPM
  • late primary spermatocytes: 48 nCPM
  • early spermatids: 33 nCPM
  • epicardial cells: 32 nCPM

Immune cell

  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • basal ganglia: 1.2 nTPM
  • hypothalamus: 0.2 nTPM
  • amygdala: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ENTHD1.

Disease | ImmuneIEDB

Conditions an epitope on ENTHD1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.33
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENTHD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTHD1 as an antibody target. Whether an autoantibody or antibody against ENTHD1 could matter depends on whether native ENTHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTHD1 is annotated at the cell surface, where native ENTHD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENTHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENTHD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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