Seroatlas · Human Serome Atlas

ENSG00000283886

Uncharacterized protein FLJ76381

Also known as: YI018_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFD4
Gene
ENSG00000283886
Ensembl
ENSG00000283886
Chromosome
9
Canonical length
153 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for ENSG00000283886 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q8NFD4|ENSG00000283886
     1  MGGFGSRFWQ EGVWDRDLEK STRLEEDAME SEPLAGTKTR GRGRRRWEAR HGWTLPAHAS
    61  QPSPRTVVAT ATGAEVSACA GRSAGTRVAR PESQLSHLYG WDKYSNPRPS RRARAVARVH
   121  ALEQAPILCR ALRWGLTQFL RGTSPVTQSV PFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENSG00000283886 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 16 nTPM
  • retina: 12 nTPM
  • cerebral cortex: 11 nTPM
  • kidney: 11 nTPM
  • adrenal gland: 9.7 nTPM
  • parathyroid gland: 9.2 nTPM

Single-cell type

  • brain inhibitory neurons: 6.9 nCPM
  • other brain neurons: 6.3 nCPM
  • brain excitatory neurons: 5.9 nCPM
  • oligodendrocytes: 5.5 nCPM
  • oligodendrocyte progenitor cells: 4.9 nCPM
  • astrocytes: 3.4 nCPM

Immune cell

  • naive B-cell: 5.8 nTPM
  • memory B-cell: 5.3 nTPM
  • NK-cell: 4.7 nTPM
  • naive CD4 T-cell: 4 nTPM
  • naive CD8 T-cell: 4 nTPM
  • T-reg: 3.8 nTPM

Brain region

  • white matter: 25 nTPM
  • midbrain: 22 nTPM
  • thalamus: 21 nTPM
  • pons: 21 nTPM
  • basal ganglia: 21 nTPM
  • hypothalamus: 21 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENSG00000283886 as an antibody target. Whether an autoantibody or antibody against ENSG00000283886 could matter depends on whether native ENSG00000283886 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENSG00000283886 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENSG00000283886 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENSG00000283886. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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