Seroatlas · Human Serome Atlas

ENSG00000268674

FAM231A/C-like protein LOC102723383

Also known as: F231L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMU3
Gene
ENSG00000268674
Ensembl
ENSG00000268674
Chromosome
Unmapped
Canonical length
169 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ENSG00000268674 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>P0DMU3|ENSG00000268674
     1  MVSSKGLWKE RPSAHTSECF STTACPVAFI LLVWNSQTPA GLQSLCTGRH PSLSARAQRA
    61  GPRASREEGT FWTERVGQER WLIRSGSSQN ESQEDQGAGL ISQAGLKADN RRESSTWANE
   121  VEDRRPQCTP ALNLTPSHPH PPHSLTTFLR SVIGIQIPPG LVAAGGTVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENSG00000268674 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 9.2 nTPM
  • lymph node: 9 nTPM
  • cervix: 7.4 nTPM
  • parathyroid gland: 7.2 nTPM
  • fallopian tube: 6.6 nTPM
  • epididymis: 5.8 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • memory CD8 T-cell: 1.7 nTPM
  • NK-cell: 1.2 nTPM
  • MAIT T-cell: 1 nTPM
  • naive CD4 T-cell: 0.9 nTPM
  • naive CD8 T-cell: 0.9 nTPM
  • gdT-cell: 0.8 nTPM

Brain region

  • hypothalamus: 12 nTPM
  • midbrain: 10 nTPM
  • medulla oblongata: 9.9 nTPM
  • pons: 9.2 nTPM
  • basal ganglia: 8.2 nTPM
  • thalamus: 7.9 nTPM

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4741
  • Domain of unknown function (DUF4741)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENSG00000268674 as an antibody target. Whether an autoantibody or antibody against ENSG00000268674 could matter depends on whether native ENSG00000268674 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENSG00000268674 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENSG00000268674 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENSG00000268674. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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