ENSA

Protein identityUniProt · HPA

UniProt accession

O43768

Gene

ENSA

Ensembl

ENSG00000143420

Chromosome

1

Canonical length

121 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Microtubules,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>O43768|ENSA
     1  MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK
    61  GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV
   121  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENSA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

323 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0.35

gnomAD missense Z

1.31

DepMap mean gene effect

-0.28

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell division
• G2/M transition of mitotic cell cycle
• mitotic cell cycle
• regulation of insulin secretion
• response to nutrient

Molecular functions

• ion channel inhibitor activity
• phosphatase inhibitor activity
• potassium channel inhibitor activity
• protein phosphatase 2A binding
• protein phosphatase inhibitor activity
• protein phosphatase regulator activity
• signaling receptor binding

Cellular components

• cytoplasm
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Endosulphine
• cAMP-regulated phosphoprotein/endosulfine conserved region

KeywordsUniProt

• Acetylation
• Cell cycle
• Cell division
• Cytoplasm
• Mitosis
• Phosphoprotein
• Protein phosphatase inhibitor

InteractionsUniProt · HPA

Protein binding partners of ENSA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ABCC8
• SNCA
• PPP2R2D