ENHO
Adropin
Also known as: C9orf165, ENHO_HUMAN, UNQ470
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UWT2
- Gene
- ENHO
- Ensembl
- ENSG00000168913
- Chromosome
- 9
- Canonical length
- 76 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in brain
OverviewNCBI Gene
Predicted to enable hormone activity. Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
76 residues, UniProt reviewed canonical sequence.
>Q6UWT2|ENHO
1 MGAAISQGAL IAIVCNGLVG FLLLLLWVIL CWACHSRSAD VDSLSESSPN SSPGPCPEKA
61 PPPQKPSHEG SYLLQPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ENHO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 589 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 589 nTPM
- amygdala: 587 nTPM
- cerebral cortex: 487 nTPM
- midbrain: 483 nTPM
- hypothalamus: 369 nTPM
- hippocampal formation: 363 nTPM
Single-cell type
- bergmann glia: 122 nCPM
- astrocytes: 95 nCPM
- müller glia: 69 nCPM
- oligodendrocyte progenitor cells: 51 nCPM
- prostatic glandular cells: 38 nCPM
- cdc: 38 nCPM
Immune cell
- myeloid DC: 28 nTPM
- NK-cell: 3.7 nTPM
- intermediate monocyte: 3.5 nTPM
- plasmacytoid DC: 1.5 nTPM
- non-classical monocyte: 1 nTPM
- total PBMC: 0.7 nTPM
Brain region
- thalamus: 461 nTPM
- basal ganglia: 368 nTPM
- midbrain: 346 nTPM
- medulla oblongata: 326 nTPM
- amygdala: 294 nTPM
- spinal cord: 288 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.86
- gnomAD pLI
- 0.11
- gnomAD missense Z
- 0.56
- DepMap mean gene effect
- -0.2
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Adropin
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ENHO as an antibody target. Whether an autoantibody or antibody against ENHO could matter depends on whether native ENHO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ENHO is annotated as secreted, so native ENHO circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ENHO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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