EMX1

Protein identityUniProt · HPA

UniProt accession

Q04741

Gene

EMX1

Ensembl

ENSG00000135638

Chromosome

2

Canonical length

290 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system development; neuroepithelial cell differentiation; and regulation of oligodendrocyte progenitor proliferation. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q04741|EMX1
     1  MCLAGCTPRK AAAPGRGALP RARLPRTAPA AATMFQPAAK RGFTIESLVA KDGGTGGGTG
    61  GGGAGSHLLA AAASEEPLRP TALNYPHPSA AEAAFVSGFP AAAAAGAGRS LYGGPELVFP
   121  EAMNHPALTV HPAHQLGASP LQPPHSFFGA QHRDPLHFYP WVLRNRFFGH RFQASDVPQD
   181  GLLLHGPFAR KPKRIRTAFS PSQLLRLERA FEKNHYVVGA ERKQLAGSLS LSETQVKVWF
   241  QNRRTKYKRQ KLEEEGPESE QKKKGSHHIN RWRIATKQAN GEDIDVTSND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

40 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.9

gnomAD missense Z

1.67

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain development
• brain morphogenesis
• central nervous system development
• cerebral cortex neuron differentiation
• cerebral cortex regionalization
• homeostasis of number of cells
• in utero embryonic development
• neuroepithelial cell differentiation
• neuron differentiation
• neuron projection extension
• post-embryonic development
• radial glial cell differentiation
• regulation of oligodendrocyte progenitor proliferation
• regulation of transcription by RNA polymerase II
• response to xenobiotic stimulus

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• chromosome
• cytoplasm
• nucleolus
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain, metazoa
• EMX/VAX/Noto Homeobox Transcription Factors
• Homeodomain

KeywordsUniProt

• Cytoplasm
• Developmental protein
• DNA-binding
• Homeobox
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of EMX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• WRD11