EMCN
Endomucin
Also known as: MUC14, MUCEN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9ULC0
- Gene
- EMCN
- Ensembl
- ENSG00000164035
- Chromosome
- 4
- Canonical length
- 261 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
261 residues, UniProt reviewed canonical sequence.
>Q9ULC0|EMCN
1 MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK NVVTPTTGTT
61 PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS IISNVTVTSV TLPNAVSTLQ
121 SSKPKTETQS SIKTTEIPGS VLQPDASPSK TGTLTSIPVT IPENTSQSQV IGTEGGKNAS
181 TSATSRSYSS IILPVVIALI VITLSVFVLV GLYRMCWKAD PGTPENGNDQ PQSDKESVKL
241 LTVKTISHES GEHSAQGKTK NLocalizationUniProt · AlphaFold · HPA
Whether an antibody against EMCN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 74 nTPM
Expression across tissuesHPA
Tissue
- kidney: 74 nTPM
- lung: 46 nTPM
- adipose tissue: 43 nTPM
- thyroid gland: 41 nTPM
- tongue: 37 nTPM
- smooth muscle: 36 nTPM
Single-cell type
- vascular endothelial cells: 971 nCPM
- lymphatic endothelial cells: 251 nCPM
- oocytes: 244 nCPM
- tuft cells: 173 nCPM
- hematopoietic stem cells: 129 nCPM
- thymic myoid cells: 57 nCPM
Immune cell
- basophil: 0.3 nTPM
- NK-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- thalamus: 12 nTPM
- pons: 11 nTPM
- medulla oblongata: 9.1 nTPM
- choroid plexus: 8.6 nTPM
- hypothalamus: 7.9 nTPM
- white matter: 7.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.96
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.55
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Endomucin
- Endomucin
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EMCN as an antibody target. Whether an autoantibody or antibody against EMCN could matter depends on whether native EMCN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EMCN is annotated at the cell surface, where native EMCN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label EMCN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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