Seroatlas · Human Serome Atlas

ELSPBP1

Epididymal sperm-binding protein 1

Also known as: E12, EDDM12, ESPB1_HUMAN, HE12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BH3
Gene: ELSPBP1
Ensembl: ENSG00000169393
Chromosome: 19
Canonical length: 223 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

The protein encoded by this gene belongs to the sperm-coating protein family of epididymal origin. This protein and its canine homolog are the first known examples of proteins with four tandemly arranged fibronectin type 2 (Fn2) domains in the Fn2-module protein family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q96BH3|ELSPBP1
     1  MTRWSSYLLG WTTFLLYSYE SSGGMHEECV FPFTYKGSVY FTCTHIHSLS PWCATRAVYN
    61  GQWKYCQSED YPRCIFPFIY RGKAYNSCIS QGSFLGSLWC SVTSVFDEKQ QWKFCETNEY
   121  GGNSLRKPCI FPSIYRNNVV SDCMEDESNK LWCPTTENMD KDGKWSFCAD TRISALVPGF
   181  PCHFPFNYKN KNYFNCTNEG SKENLVWCAT SYNYDQDHTW VYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELSPBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 2,669 nTPM

Expression across tissuesHPA

Tissue

epididymis: 2,669 nTPM
retina: 69 nTPM
seminal vesicle: 1 nTPM
testis: 0.9 nTPM
hypothalamus: 0.2 nTPM
spinal cord: 0.2 nTPM

Single-cell type

epididymal principal cells: 3,233 nCPM
rod photoreceptor cells: 93 nCPM
epididymal clear cells: 43 nCPM
late spermatids: 40 nCPM
early spermatids: 38 nCPM
epididymal basal cells: 33 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.6 nTPM
white matter: 0.5 nTPM
spinal cord: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

heparin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELSPBP1 as an antibody target. Whether an autoantibody or antibody against ELSPBP1 could matter depends on whether native ELSPBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELSPBP1 is annotated as secreted, so native ELSPBP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ELSPBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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