Seroatlas · Human Serome Atlas

ELOVL6

Very long chain fatty acid elongase 6

Also known as: ELOV6_HUMAN, FLJ23378, LCE, MGC5487

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H5J4
Gene: ELOVL6
Ensembl: ENSG00000170522
Chromosome: 4
Canonical length: 265 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q9H5J4|ELOVL6
     1  MNMSVLTLQE YEFEKQFNEN EAIQWMQENW KKSFLFSALY AAFIFGGRHL MNKRAKFELR
    61  KPLVLWSLTL AVFSIFGALR TGAYMVYILM TKGLKQSVCD QGFYNGPVSK FWAYAFVLSK
   121  APELGDTIFI ILRKQKLIFL HWYHHITVLL YSWYSYKDMV AGGGWFMTMN YGVHAVMYSY
   181  YALRAAGFRV SRKFAMFITL SQITQMLMGC VVNYLVFCWM QHDQCHSHFQ NIFWSSLMYL
   241  SYLVLFCHFF FEAYIGKMRK TTKAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELOVL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

liver: 31 nTPM
stomach: 13 nTPM
spinal cord: 13 nTPM
retina: 11 nTPM
colon: 11 nTPM
skin: 11 nTPM

Single-cell type

foveolar cells: 278 nCPM
erythrocyte progenitors: 193 nCPM
megakaryocyte-erythroid progenitors: 189 nCPM
esophageal apical cells: 188 nCPM
retinal ganglion cells: 158 nCPM
urothelial cells: 154 nCPM

Immune cell

NK-cell: 3.3 nTPM
MAIT T-cell: 2.6 nTPM
gdT-cell: 2.4 nTPM
memory CD8 T-cell: 1.3 nTPM
memory CD4 T-cell: 1 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

cerebral cortex: 18 nTPM
white matter: 18 nTPM
pons: 15 nTPM
spinal cord: 14 nTPM
medulla oblongata: 13 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 3.04
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

fatty acid elongase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

ELO family
ELO family, conserved site
GNS1/SUR4 family
Elongation of very long chain fatty acids protein 6

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELOVL6 as an antibody target. Whether an autoantibody or antibody against ELOVL6 could matter depends on whether native ELOVL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELOVL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELOVL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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