ELOF1
Transcription elongation factor 1 homolog
Also known as: ELF1, ELOF1_HUMAN, MGC4549
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P60002
- Gene
- ELOF1
- Ensembl
- ENSG00000130165
- Chromosome
- 19
- Canonical length
- 83 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
83 residues, UniProt reviewed canonical sequence.
>P60002|ELOF1
1 MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC TVCLEEFQTP
61 ITYLSEPVDV YSDWIDACEA ANQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ELOF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 194 nTPM
Expression across tissuesHPA
Tissue
- testis: 194 nTPM
- choroid plexus: 84 nTPM
- cerebellum: 79 nTPM
- liver: 77 nTPM
- pancreas: 76 nTPM
- pituitary gland: 71 nTPM
Single-cell type
- late spermatids: 2,533 nCPM
- late primary spermatocytes: 643 nCPM
- early spermatids: 455 nCPM
- oocytes: 415 nCPM
- esophageal apical cells: 151 nCPM
- esophageal suprabasal cells: 128 nCPM
Immune cell
- memory B-cell: 198 nTPM
- plasmacytoid DC: 191 nTPM
- naive B-cell: 163 nTPM
- T-reg: 155 nTPM
- non-classical monocyte: 149 nTPM
- total PBMC: 148 nTPM
Brain region
- white matter: 114 nTPM
- cerebral cortex: 102 nTPM
- cerebellum: 95 nTPM
- hypothalamus: 93 nTPM
- choroid plexus: 85 nTPM
- pons: 84 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.34
- gnomAD pLI
- 0.09
- gnomAD missense Z
- 1.27
- DepMap mean gene effect
- -0.36
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Transcription elongation factor 1
- Transcription elongation factor 1 superfamily
- Transcription elongation factor Elf1 like
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ELOF1 as an antibody target. Whether an autoantibody or antibody against ELOF1 could matter depends on whether native ELOF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ELOF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ELOF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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