ELOA2

Protein identityUniProt · HPA

UniProt accession

Q8IYF1

Gene

ELOA2

Ensembl

ENSG00000206181

Chromosome

18

Canonical length

753 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

753 residues, UniProt reviewed canonical sequence.

>Q8IYF1|ELOA2
     1  MAAGSTTLHA VEKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR KTVKRLRKHQ
    61  HVGDFARDLA ARWKKLVLVD RNTRPGPQDP EESASRQRFG EALQDQEKAW GFPENATAPR
   121  SPSHSPEHRR TARRTPPGQQ RPHPRSHSRE PRAERKCPRI APADSGRYRA SPTRTAPLRM
   181  PEGPEPAAPG KQPGRGHTHA AQGGPLLCPG CQGQPQGKAV VSHSKGHKSS RQEKRPLCAQ
   241  GDWHSPTLIR EKSCGACLRE ETPRMPSWAS ARDRQPSDFK TDKEGGQAGS GQRVPALEEA
   301  PDSHQKRPQH SHSNKKRPSL DGRDPGNGTH GLSPEEKEQL SNDRETQEGK PPTAHLDRTS
   361  VSSLSEVEEV DMAEEFEQPT LSCEKYLTYD QLRKQKKKTG KSATTALGDK QRKANESKGT
   421  RESWDSAKKL PPVQESQSER LQAAGADSAG PKTVPSHVFS ELWDLSEAWM QANYDPLSDS
   481  DSMTSQAKPE ALSSPKFREE AAFPGRRVNA KMPVYSGSRP ACQLQVPTLR QQCAQVLRNN
   541  PDALSDVGEV PYWVLEPVLE GWRPDQLYRR KKDNHALVRE TDELRRNHCF QDFKEEKPQE
   601  NKTWREQYLR LPDAPEQRLR VMTTNIRSAR GNNPNGREAK MICFKSVAKT PYDTSRRQEK
   661  SAGDADPENG EIKPASKPAG SSHTPSSQSS SGGGRDSSSS ILRWLPEKRA NPCLSSSNEH
   721  AAPAAKTRKQ AAKKVAPLMA KAIRDYKRRF SRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELOA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

3.8 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0

gnomAD pLI

0

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of DNA-templated transcription elongation
• transcription by RNA polymerase II
• transcription elongation by RNA polymerase II

Cellular components

• elongin complex
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
• RNA polymerase II transcription factor SIII, subunit A
• Transcription factor IIS, N-terminal
• TFIIS/LEDGF domain superfamily
• Elongin-A domain-containing protein
• RNA polymerase II transcription factor SIII (Elongin) subunit A
• TFIIS helical bundle-like domain

KeywordsUniProt

• Nucleus
• Transcription
• Transcription regulation