Seroatlas · Human Serome Atlas

ELAPOR2

Endosome/lysosome-associated apoptosis and autophagy regulator family member 2

Also known as: EIG121L, ELAP2_HUMAN, FLJ31340, KIAA1324L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MWY0
Gene: ELAPOR2
Ensembl: ENSG00000164659
Chromosome: 7
Canonical length: 1029 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable BMP receptor binding activity. Predicted to be involved in negative regulation of nervous system development; positive regulation of BMP signaling pathway; and positive regulation of epidermis development. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1029 residues, UniProt reviewed canonical sequence.

>A8MWY0|ELAPOR2
     1  MLFRARGPVR GRGWGRPAEA PRRGRSPPWS PAWICCWALA GCQAAWAGDL PSSSSRPLPP
    61  CQEKDYHFEY TECDSSGSRW RVAIPNSAVD CSGLPDPVRG KECTFSCASG EYLEMKNQVC
   121  SKCGEGTYSL GSGIKFDEWD ELPAGFSNIA TFMDTVVGPS DSRPDGCNNS SWIPRGNYIE
   181  SNRDDCTVSL IYAVHLKKSG YVFFEYQYVD NNIFFEFFIQ NDQCQEMDTT TDKWVKLTDN
   241  GEWGSHSVML KSGTNILYWR TTGILMGSKA VKPVLVKNIT IEGVAYTSEC FPCKPGTFSN
   301  KPGSFNCQVC PRNTYSEKGA KECIRCKDDS QFSEEGSSEC TERPPCTTKD YFQIHTPCDE
   361  EGKTQIMYKW IEPKICREDL TDAIRLPPSG EKKDCPPCNP GFYNNGSSSC HPCPPGTFSD
   421  GTKECRPCPA GTEPALGFEY KWWNVLPGNM KTSCFNVGNS KCDGMNGWEV AGDHIQSGAG
   481  GSDNDYLILN LHIPGFKPPT SMTGATGSEL GRITFVFETL CSADCVLYFM VDINRKSTNV
   541  VESWGGTKEK QAYTHIIFKN ATFTFTWAFQ RTNQGQDNRR FINDMVKIYS ITATNAVDGV
   601  ASSCRACALG SEQSGSSCVP CPPGHYIEKE TNQCKECPPD TYLSIHQVYG KEACIPCGPG
   661  SKNNQDHSVC YSDCFFYHEK ENQSLHYDFS NLSSVGSLMN GPSFTSKGTK YFHFFNISLC
   721  GHEGKKMALC TNNITDFTVK EIVAGSDDYT NLVGAFVCQS TIIPSESKGF RAALSSQSII
   781  LADTFIGVTV ETTLKNINIK EDMFPVPTSQ IPDVHFFYKS STATTSCING RSTAVKMRCN
   841  PTKSGAGVIS VPSKCPAGTC DGCTFYFLWE SAEACPLCTE HDFHEIEGAC KRGFQETLYV
   901  WNEPKWCIKG ISLPEKKLAT CETVDFWLKV GAGVGAFTAV LLVALTCYFW KKNQKLEYKY
   961  SKLVMTTNSK ECELPAADSC AIMEGEDNEE EVVYSNKQSL LGKLKSLATK EKEDHFESVQ
  1021  LKTSRSPNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELAPOR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

lung: 21 nTPM
spinal cord: 14 nTPM
cerebral cortex: 12 nTPM
adipose tissue: 9.6 nTPM
midbrain: 8 nTPM
parathyroid gland: 7.8 nTPM

Single-cell type

oligodendrocytes: 363 nCPM
alveolar cells type 2: 298 nCPM
lactotrophs: 240 nCPM
corticotrophs: 218 nCPM
thyrotrophs: 165 nCPM
somatotrophs: 160 nCPM

Immune cell

MAIT T-cell: 2.7 nTPM
NK-cell: 2.3 nTPM
naive B-cell: 1.9 nTPM
memory CD4 T-cell: 0.9 nTPM
naive CD4 T-cell: 0.9 nTPM
memory CD8 T-cell: 0.6 nTPM

Brain region

white matter: 123 nTPM
basal ganglia: 74 nTPM
thalamus: 67 nTPM
pons: 62 nTPM
medulla oblongata: 60 nTPM
cerebellum: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of BMP signaling pathway
positive regulation of epidermis development
negative regulation of nervous system development

Molecular functions

BMP receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELAPOR2 as an antibody target. Whether an autoantibody or antibody against ELAPOR2 could matter depends on whether native ELAPOR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELAPOR2 is annotated at the cell surface, where native ELAPOR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ELAPOR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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