Seroatlas · Human Serome Atlas

ELAPOR1

Endosome/lysosome-associated apoptosis and autophagy regulator 1

Also known as: EIG121, ELAP1_HUMAN, KIAA1324, maba1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXG2
Gene: ELAPOR1
Ensembl: ENSG00000116299
Chromosome: 1
Canonical length: 1013 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

1013 residues, UniProt reviewed canonical sequence.

>Q6UXG2|ELAPOR1
     1  MAEPGHSHHL SARVRGRTER RIPRLWRLLL WAGTAFQVTQ GTGPELHACK ESEYHYEYTA
    61  CDSTGSRWRV AVPHTPGLCT SLPDPIKGTE CSFSCNAGEF LDMKDQSCKP CAEGRYSLGT
   121  GIRFDEWDEL PHGFASLSAN MELDDSAAES TGNCTSSKWV PRGDYIASNT DECTATLMYA
   181  VNLKQSGTVN FEYYYPDSSI IFEFFVQNDQ CQPNADDSRW MKTTEKGWEF HSVELNRGNN
   241  VLYWRTTAFS VWTKVPKPVL VRNIAITGVA YTSECFPCKP GTYADKQGSS FCKLCPANSY
   301  SNKGETSCHQ CDPDKYSEKG SSSCNVRPAC TDKDYFYTHT ACDANGETQL MYKWAKPKIC
   361  SEDLEGAVKL PASGVKTHCP PCNPGFFKTN NSTCQPCPYG SYSNGSDCTR CPAGTEPAVG
   421  FEYKWWNTLP TNMETTVLSG INFEYKGMTG WEVAGDHIYT AAGASDNDFM ILTLVVPGFR
   481  PPQSVMADTE NKEVARITFV FETLCSVNCE LYFMVGVNSR TNTPVETWKG SKGKQSYTYI
   541  IEENTTTSFT WAFQRTTFHE ASRKYTNDVA KIYSINVTNV MNGVASYCRP CALEASDVGS
   601  SCTSCPAGYY IDRDSGTCHS CPTNTILKAH QPYGVQACVP CGPGTKNNKI HSLCYNDCTF
   661  SRNTPTRTFN YNFSALANTV TLAGGPSFTS KGLKYFHHFT LSLCGNQGRK MSVCTDNVTD
   721  LRIPEGESGF SKSITAYVCQ AVIIPPEVTG YKAGVSSQPV SLADRLIGVT TDMTLDGITS
   781  PAELFHLESL GIPDVIFFYR SNDVTQSCSS GRSTTIRVRC SPQKTVPGSL LLPGTCSDGT
   841  CDGCNFHFLW ESAAACPLCS VADYHAIVSS CVAGIQKTTY VWREPKLCSG GISLPEQRVT
   901  ICKTIDFWLK VGISAGTCTA ILLTVLTCYF WKKNQKLEYK YSKLVMNATL KDCDLPAADS
   961  CAIMEGEDVE DDLIFTSKKS LFGKIKSFTS KRTPDGFDSV PLKTSSGGLD MDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELAPOR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 156 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 156 nTPM
pancreas: 148 nTPM
stomach: 83 nTPM
cervix: 66 nTPM
breast: 53 nTPM
prostate: 46 nTPM

Single-cell type

prostatic glandular cells: 738 nCPM
salivary acinar cells: 524 nCPM
paneth cells: 507 nCPM
lacrimal acinar cells: 486 nCPM
corticotrophs: 467 nCPM
lactotrophs: 453 nCPM

Immune cell

neutrophil: 66 nTPM
T-reg: 9.8 nTPM
MAIT T-cell: 7.7 nTPM
memory CD4 T-cell: 7.5 nTPM
gdT-cell: 4.6 nTPM
naive CD4 T-cell: 3.3 nTPM

Brain region

hypothalamus: 41 nTPM
cerebral cortex: 23 nTPM
hippocampal formation: 23 nTPM
basal ganglia: 22 nTPM
amygdala: 18 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELAPOR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPA5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELAPOR1 as an antibody target. Whether an autoantibody or antibody against ELAPOR1 could matter depends on whether native ELAPOR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELAPOR1 is annotated at the cell surface, where native ELAPOR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ELAPOR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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