ELAC1
Zinc phosphodiesterase ELAC protein 1
Also known as: D29, RNZ1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H777
- Gene
- ELAC1
- Ensembl
- ENSG00000141642
- Chromosome
- 18
- Canonical length
- 363 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables tRNA-specific ribonuclease activity. Involved in rescue of stalled ribosome and tRNA 3'-end processing. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
363 residues, UniProt reviewed canonical sequence.
>Q9H777|ELAC1
1 MSMDVTFLGT GAAYPSPTRG ASAVVLRCEG ECWLFDCGEG TQTQLMKSQL KAGRITKIFI
61 THLHGDHFFG LPGLLCTISL QSGSMVSKQP IEIYGPVGLR DFIWRTMELS HTELVFHYVV
121 HELVPTADQC PAEELKEFAH VNRADSPPKE EQGRTILLDS EENSYLLFDD EQFVVKAFRL
181 FHRIPSFGFS VVEKKRPGKL NAQKLKDLGV PPGPAYGKLK NGISVVLENG VTISPQDVLK
241 KPIVGRKICI LGDCSGVVGD GGVKLCFEAD LLIHEATLDD AQMDKAKEHG HSTPQMAATF
301 AKLCRAKRLV LTHFSQRYKP VALAREGETD GIAELKKQAE SVLDLQEVTL AEDFMVISIP
361 IKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ELAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 12 nTPM
- parathyroid gland: 11 nTPM
- thyroid gland: 9.5 nTPM
- liver: 9.3 nTPM
- pancreas: 8.2 nTPM
- kidney: 7.5 nTPM
Single-cell type
- conjunctival goblet cells: 2.9 nCPM
- late spermatids: 2.7 nCPM
- medullary thymic epithelial cells: 2.4 nCPM
- early spermatids: 2 nCPM
- pdcs: 1.9 nCPM
- basal prostatic cells: 1.2 nCPM
Immune cell
- NK-cell: 21 nTPM
- memory B-cell: 19 nTPM
- naive CD8 T-cell: 18 nTPM
- MAIT T-cell: 17 nTPM
- naive B-cell: 17 nTPM
- myeloid DC: 15 nTPM
Brain region
- hypothalamus: 14 nTPM
- choroid plexus: 13 nTPM
- white matter: 13 nTPM
- cerebral cortex: 12 nTPM
- hippocampal formation: 12 nTPM
- amygdala: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.88
- gnomAD missense Z
- 0.44
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ELAC1 as an antibody target. Whether an autoantibody or antibody against ELAC1 could matter depends on whether native ELAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ELAC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ELAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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