Seroatlas · Human Serome Atlas

EIF5AL1

Eukaryotic translation initiation factor 5A-1-like

Also known as: bA342M3.3, EIF5AP1, IF5AL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IS14
Gene: EIF5AL1
Ensembl: ENSG00000253626
Chromosome: 10
Canonical length: 154 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in endoplasmic reticulum membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q6IS14|EIF5AL1
     1  MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGWPCKI VEMSASKTGK HGHAKVHLVG
    61  IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVPE DLRLPEGDLG
   121  KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF5AL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 9.9 nTPM

Expression across tissuesHPA

Tissue

testis: 9.9 nTPM
esophagus: 1.3 nTPM
skeletal muscle: 1.3 nTPM
liver: 1.2 nTPM
skin: 0.9 nTPM
heart muscle: 0.8 nTPM

Single-cell type

late primary spermatocytes: 62 nCPM
enteric transient amplifying cells: 45 nCPM
enteric stem cells: 36 nCPM
colonocytes: 36 nCPM
goblet cells: 36 nCPM
esophageal basal cells: 34 nCPM

Immune cell

plasmacytoid DC: 2.5 nTPM
intermediate monocyte: 2 nTPM
NK-cell: 1.7 nTPM
myeloid DC: 1.6 nTPM
MAIT T-cell: 1.4 nTPM
memory B-cell: 1.3 nTPM

Brain region

cerebellum: 2.8 nTPM
cerebral cortex: 2.2 nTPM
amygdala: 2 nTPM
basal ganglia: 2 nTPM
hippocampal formation: 1.9 nTPM
white matter: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0.34
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF5AL1 as an antibody target. Whether an autoantibody or antibody against EIF5AL1 could matter depends on whether native EIF5AL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF5AL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF5AL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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