Seroatlas · Human Serome Atlas

EIF1B

Eukaryotic translation initiation factor 1b

Also known as: EIF1B_HUMAN, GC20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60739
Gene
EIF1B
Ensembl
ENSG00000114784
Chromosome
3
Canonical length
113 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in regulation of translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>O60739|EIF1B
     1  MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
    61  KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV GIVKEEQLKV HGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
340 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 340 nTPM
  • bone marrow: 209 nTPM
  • skeletal muscle: 149 nTPM
  • tongue: 137 nTPM
  • cerebellum: 123 nTPM
  • cerebral cortex: 123 nTPM

Single-cell type

  • oocytes: 1,308 nCPM
  • platelets: 625 nCPM
  • tuft cells: 576 nCPM
  • early primary spermatocytes: 506 nCPM
  • erythrocytes: 273 nCPM
  • mast cells: 264 nCPM

Immune cell

  • eosinophil: 138 nTPM
  • neutrophil: 134 nTPM
  • memory B-cell: 96 nTPM
  • basophil: 93 nTPM
  • naive B-cell: 84 nTPM
  • plasmacytoid DC: 73 nTPM

Brain region

  • hypothalamus: 162 nTPM
  • pons: 133 nTPM
  • medulla oblongata: 124 nTPM
  • cerebral cortex: 122 nTPM
  • midbrain: 110 nTPM
  • white matter: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0.5
gnomAD missense Z
1.9
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF1B as an antibody target. Whether an autoantibody or antibody against EIF1B could matter depends on whether native EIF1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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