EI24

Protein identityUniProt · HPA

UniProt accession

O14681

Gene

EI24

Ensembl

ENSG00000149547

Chromosome

11

Canonical length

340 aa

Protein class

Cancer-related genes, Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Endoplasmic reticulum,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>O14681|EI24
     1  MADSVKTFLQ DLARGIKDSI WGICTISKLD ARIQQKREEQ RRRRASSVLA QRRAQSIERK
    61  QESEPRIVSR IFQCCAWNGG VFWFSLLLFY RVFIPVLQSV TARIIGDPSL HGDVWSWLEF
   121  FLTSIFSALW VLPLFVLSKV VNAIWFQDIA DLAFEVSGRK PHPFPSVSKI IADMLFNLLL
   181  QALFLIQGMF VSLFPIHLVG QLVSLLHMSL LYSLYCFEYR WFNKGIEMHQ RLSNIERNWP
   241  YYFGFGLPLA FLTAMQSSYI ISGCLFSILF PLFIISANEA KTPGKAYLFQ LRLFSLVVFL
   301  SNRLFHKTVY LQSALSSSTS AEKFPSPHPS PAKLKATAGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EI24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

5

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

435 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EI24.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 36 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.73

gnomAD missense Z

2

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cellular response to UV-C
• intrinsic apoptotic signaling pathway in response to DNA damage
• macroautophagy
• negative regulation of cell growth
• negative regulation of protein import into nucleus
• neuromuscular process controlling balance
• positive regulation of intrinsic apoptotic signaling pathway
• response to xenobiotic stimulus

Molecular functions

• importin-alpha family protein binding

Cellular components

• cytosol
• endoplasmic reticulum
• endoplasmic reticulum membrane
• Golgi apparatus
• membrane
• nuclear membrane

Protein domainsUniProt · Pfam · InterPro

• Sulfate transporter CysZ/Etoposide-induced protein 2.4
• Sulfate transporter CysZ/Etoposide-induced protein 2.4

KeywordsUniProt

• Acetylation
• Apoptosis
• Autophagy
• Cytoplasm
• Endoplasmic reticulum
• Membrane
• Nucleus
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of EI24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BCL2