Seroatlas · Human Serome Atlas

EGR3

Early growth response protein 3

Also known as: EGR3_HUMAN, PILOT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06889
Gene
EGR3
Ensembl
ENSG00000179388
Chromosome
8
Canonical length
387 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q06889|EGR3
     1  MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVVHYNQMA TENVMDIGLT
    61  NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL
   121  STQTSTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK
   181  PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH
   241  PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT
   301  GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE
   361  KKAEKGGAPS ASSAPPVSLA PVVTTCA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EGR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • skin: 42 nTPM
  • gallbladder: 28 nTPM
  • adipose tissue: 27 nTPM
  • cerebral cortex: 26 nTPM
  • adrenal gland: 23 nTPM
  • blood vessel: 19 nTPM

Single-cell type

  • neutrophils: 291 nCPM
  • breast secretory cells: 212 nCPM
  • endometrial luminal cells: 144 nCPM
  • endometrial glandular cells: 123 nCPM
  • neuroendocrine cells: 121 nCPM
  • endometrial secretory cells: 121 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 112 nTPM
  • hippocampal formation: 52 nTPM
  • basal ganglia: 38 nTPM
  • amygdala: 33 nTPM
  • white matter: 28 nTPM
  • medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.95
gnomAD missense Z
3.38
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EGR3 as an antibody target. Whether an autoantibody or antibody against EGR3 could matter depends on whether native EGR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EGR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EGR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EGR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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