Seroatlas · Human Serome Atlas

EGFEM1P

Putative EGF-like and EMI domain-containing protein 1

Also known as: EGFEM_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0D2K5
Gene: EGFEM1P
Canonical length: 195 aa

OverviewNCBI Gene

No narrative summary is available for EGFEM1P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q0D2K5|EGFEM1P
     1  MDELRWYHIT VCLDHIFGHN CSLSCKDCMN GGKCQEGKSE CSCPAGCRVI LCNENCLEGA
    61  YGAGCTSECQ CVEENTLECS AKNGSCTCKS GYQGNRCQKD GLWGPEGWFS SAPCENGGQC
   121  NKKTGNCDCT PDYTRKSCTI LRCISLTNLA LSRRSSPMKY QQNVSSHREV RQRQQCSSDR
   181  PFKKLLCKFS FKIGM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EGFEM1P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

scavenger receptor activity

Protein domainsUniProt · Pfam · InterPro

MEGF10/SREC1/2-like

KeywordsUniProt

EGF-like domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EGFEM1P as an antibody target. Whether an autoantibody or antibody against EGFEM1P could matter depends on whether native EGFEM1P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EGFEM1P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EGFEM1P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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