Seroatlas · Human Serome Atlas

EFR3B

Protein EFR3 homolog B

Also known as: EFR3B_HUMAN, FLJ37871, KIAA0953

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2G0
Gene
EFR3B
Ensembl
ENSG00000084710
Chromosome
2
Canonical length
817 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in actin cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

817 residues, UniProt reviewed canonical sequence.

>Q9Y2G0|EFR3B
     1  MYGVCGCCGA LRPRYKRLVD NIFPEDPEDG LVKTNMEKLT FYALSAPEKL DRIGAYLSER
    61  LIRDVGRHRY GYVCIAMEAL DQLLMACHCQ SINLFVESFL KMVAKLLESE KPNLQILGTN
   121  SFVKFANIEE DTPSYHRSYD FFVSRFSEMC HSSHDDLEIK TKIRMSGIKG LQGVVRKTVN
   181  DELQANIWDP QHMDKIVPSL LFNLQHVEEA ESRSPSPLQA PEKEKESPAE LAERCLRELL
   241  GRAAFGNIKN AIKPVLIHLD NHSLWEPKVF AIRCFKIIMY SIQPQHSHLV IQQLLGHLDA
   301  NSRSAATVRA GIVEVLSEAA VIAATGSVGP TVLEMFNTLL RQLRLSIDYA LTGSYDGAVS
   361  LGTKIIKEHE ERMFQEAVIK TVGSFASTLP TYQRSEVILF IMSKVPRPSL HQAVDTGRTG
   421  ENRNRLTQIM LLKSLLQVST GFQCNNMMSA LPSNFLDRLL STALMEDAEI RLFVLEILIS
   481  FIDRHGNRHK FSTISTLSDI SVLKLKVDKC SRQDTVFMKK HSQQLYRHIY LSCKEETNVQ
   541  KHYEALYGLL ALISIELANE EVVVDLIRLV LAVQDVAQVN EENLPVYNRC ALYALGAAYL
   601  NLISQLTTVP AFCQHIHEVI ETRKKEAPYM LPEDVFVERP RLSQNLDGVV IELLFRQSKI
   661  SEVLGGSGYN SDRLCLPYIP QLTDEDRLSK RRSIGETISL QVEVESRNSP EKEERVPAEE
   721  ITYETLKKAI VDSVAVEEQE RERRRQVVEK FQKAPFEEIA AHCGARASLL QSKLNQIFEI
   781  TIRPPPSPSG TITAAYGQPQ NHSIPVYEMK FPDLCVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFR3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 33 nTPM
  • cerebellum: 26 nTPM
  • cerebral cortex: 24 nTPM
  • hippocampal formation: 22 nTPM
  • amygdala: 19 nTPM
  • skeletal muscle: 19 nTPM

Single-cell type

  • retinal pigment epithelial cells: 537 nCPM
  • retinal ganglion cells: 240 nCPM
  • astrocytes: 208 nCPM
  • brain inhibitory neurons: 164 nCPM
  • brain excitatory neurons: 135 nCPM
  • lactotrophs: 125 nCPM

Immune cell

  • basophil: 1.3 nTPM
  • neutrophil: 0.4 nTPM
  • eosinophil: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM

Brain region

  • basal ganglia: 154 nTPM
  • hippocampal formation: 153 nTPM
  • pons: 143 nTPM
  • medulla oblongata: 113 nTPM
  • cerebral cortex: 105 nTPM
  • thalamus: 103 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.02
gnomAD missense Z
4.26
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFR3B as an antibody target. Whether an autoantibody or antibody against EFR3B could matter depends on whether native EFR3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFR3B is annotated at the cell surface, where native EFR3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EFR3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EFR3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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