Seroatlas · Human Serome Atlas

EFNB2

Ephrin-B2

Also known as: EFNB2_HUMAN, EPLG5, Htk-L, HTKL, LERK5, MGC126226, MGC126227, MGC126228

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52799
Gene
EFNB2
Ensembl
ENSG00000125266
Chromosome
13
Canonical length
333 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>P52799|EFNB2
     1  MAVRRDSVWK YCWGVLMVLC RTAISKSIVL EPIYWNSSNS KFLPGQGLVL YPQIGDKLDI
    61  ICPKVDSKTV GQYEYYKVYM VDKDQADRCT IKKENTPLLN CAKPDQDIKF TIKFQEFSPN
   121  LWGLEFQKNK DYYIISTSNG SLEGLDNQEG GVCQTRAMKI LMKVGQDASS AGSTRNKDPT
   181  RRPELEAGTN GRSSTTSPFV KPNPGSSTDG NSAGHSGNNI LGSEVALFAG IASGCIIFIV
   241  IIITLVVLLL KYRRRHRKHS PQHTTTLSLS TLATPKRSGN NNGSEPSDII IPLRTADSVF
   301  CPHYEKVSGD YGHPVYIVQE MPPQSPANIY YKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFNB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 15 nTPM
  • stomach: 14 nTPM
  • colon: 14 nTPM
  • lung: 13 nTPM
  • seminal vesicle: 9.9 nTPM
  • rectum: 9.3 nTPM

Single-cell type

  • vascular endothelial cells: 298 nCPM
  • prostatic glandular cells: 225 nCPM
  • foveolar cells: 209 nCPM
  • suprabasal keratinocytes: 202 nCPM
  • lymphatic endothelial cells: 192 nCPM
  • salivary basal cells: 182 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 23 nTPM
  • cerebral cortex: 22 nTPM
  • hypothalamus: 21 nTPM
  • hippocampal formation: 20 nTPM
  • white matter: 20 nTPM
  • amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
1.83
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EFNB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFNB2 as an antibody target. Whether an autoantibody or antibody against EFNB2 could matter depends on whether native EFNB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFNB2 is annotated at the cell surface, where native EFNB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EFNB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EFNB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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