Seroatlas · Human Serome Atlas

EFCAB8

EF-hand calcium-binding domain-containing protein 8

Also known as: EFCB8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MWE9
Gene
EFCAB8
Ensembl
ENSG00000215529
Chromosome
20
Canonical length
144 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>A8MWE9|EFCAB8
     1  MSSEDLAEIP QLQKLSIPHG FQNKEAASSP TPSITLSQVP DLQPGSQLFT EIHLAKIEKM
    61  FEEDINSTGA LGMDAFIKAM KKVLSSVSDE MLKELFLKVD SDCEGFVTWQ KYVDYMMREF
   121  QGKEDMRKSQ YRLHFYLPMT VVPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
3.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.4 nTPM
  • appendix: 0.3 nTPM
  • pituitary gland: 0.3 nTPM
  • small intestine: 0.3 nTPM
  • spleen: 0.3 nTPM
  • thyroid gland: 0.2 nTPM

Single-cell type

  • late primary spermatocytes: 18 nCPM
  • neutrophils: 18 nCPM
  • pituitary stem cells: 15 nCPM
  • innate lymphoid cells: 12 nCPM
  • early spermatids: 11 nCPM
  • pancreatic islet cells: 8.4 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • thalamus: 0.7 nTPM
  • white matter: 0.7 nTPM
  • cerebral cortex: 0.6 nTPM
  • medulla oblongata: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • hippocampal formation: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.2

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB8 as an antibody target. Whether an autoantibody or antibody against EFCAB8 could matter depends on whether native EFCAB8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EFCAB8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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