Seroatlas · Human Serome Atlas

EFCAB5

EF-hand calcium-binding domain-containing protein 5

Also known as: EFCB5_HUMAN, FLJ46247

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4FU69
Gene: EFCAB5
Ensembl: ENSG00000176927
Chromosome: 17
Canonical length: 1503 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Mitochondria

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1503 residues, UniProt reviewed canonical sequence.

>A4FU69|EFCAB5
     1  MNESASQEEL RPAQENRKED KERKWNLTEV KELHETLQSV PDVPVKEDTN SVVEKAMDEI
    61  KSQELNLEGQ RKISPGSIKD SKTEASGNIA IRKSAKVIFA LDETELKSKP EHTWKKNLFE
   121  RMEARAQAMQ QKIIDKENLK KELEKKAEKK LPRDNLAKEW FNTDSMTLNN TAYLLDKLLP
   181  TLVPGVENML TQVEKKKVLT EADTPSKFDP INYLGEYLIR NNPNYIKDPG MSGYQRLMKE
   241  VTEDLKIYVP DTICNRVSKM KENVKQNRKQ RESIDKIIVK VANTRKQALQ EQFDEWILDP
   301  KGMIPKSVIQ NVLQEFFQNP DFKLGSHCKQ LDITDSTEPR LNKMEFTEYI SSHIKDLKSE
   361  MFEELLKHLC HSADEFREVI KADMRRQMFA ELFLHCDHGK VGFLDRQRTL ALLELFYDHS
   421  SQMLRSLLRN PRQWPFIEFE EINLTELWGD MDNQKHIYEG FDKVLLEMNT LLSANHASKT
   481  QSKLLESPDQ PKLNEQRTST PSPNPPEQQR GVTAEQGPQR ISIEEQQQGK KPTAEQELYI
   541  ESVIEPGTHT ESTLEQGSSR RLLTEQETHR ESTTEQGQHK GSIEGQGPRR VSVSEQGSSR
   601  ESVAEQGSRR ESIAEQDRHK GSVAEQGSRR MSAAEQGSLR ESVIEEPYQK SEQGPYGEII
   661  SEEQEDIGST SQSRKDSILK STKYGEPITS EYIEVPLQEK RSWEQTYEEE IFLSSELQEE
   721  VPTLSRKDHF PETTKKEVQK DKPCEPKSQK IEGKSWSGEF FTCNWKMKYV TFEDEEQANL
   781  IYGNSRFTDL HSIIRNIQSC KEVKGRTAFN GVSFNLLQFV QLLETFVGED APLSVSETLT
   841  SFFKEGYVET EQEKMNALEQ FSQNAFQVRQ RLLLEAIFQK WDSDGSGFLD LKEVDELLYT
   901  YKEGMEKESM KKAKLHIQFP KPHPGHEVRL SSKQFQNYIE LVVSELRGNE DQVLESVVEF
   961  LMNALERSHI ESLRNSARRK WLHQIQCAAE TSGVSLEPVY SETFKALMQD AEAHGNKKIS
  1021  AHISLLEENL LLPEKGNVLL RNVACTLDDA QFVLNRVLYR DMKGISFTVV DEGKPIHVPQ
  1081  VQYHGNIFFW NQSRNKHDYN GSFLALPLQD AYMRIFGVLA VDTLRDPHEI NIFLPHEIRF
  1141  YQGVANVFST AYHYVHSREH ILHIVITGIG WLYDVTSSIT SITTYFVEPS PAQDSDYVLR
  1201  NMMVTGQLGL TEIHKNPPTI HRKSCIFRDF LFKCTDSSEV VLASACGETH IVVPLRERTG
  1261  EALGVLDFNI GQNRMLLCQE YKDLQKMMKV VQVACYEILG EFSGEIKKKY ILEIENVREV
  1321  QRAGILFFRI MLLELQESIQ LLNSMEFVSL LLYDHTLVTE PNSPQDSKSM ELEANVKLVR
  1381  DILKAVILFF HPELEFSSDF GSWDKCKFYV NKYLVNNICA FDPTAKHVEV NVQLIDEYIR
  1441  DHSRTEVWKF GNVVIEHLYH WIHICSALMK ITKQLNSGIT PPLPSKTDNY MYAKMPGEGL
  1501  QEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

testis: 8 nTPM
bone marrow: 1.2 nTPM
rectum: 1 nTPM
colon: 0.7 nTPM
cerebral cortex: 0.4 nTPM
lymph node: 0.4 nTPM

Single-cell type

late primary spermatocytes: 207 nCPM
early spermatids: 201 nCPM
late spermatids: 168 nCPM
cardiomyocytes: 146 nCPM
early primary spermatocytes: 62 nCPM
epicardial cells: 34 nCPM

Immune cell

eosinophil: 3.2 nTPM
basophil: 2.4 nTPM
naive B-cell: 0.9 nTPM
memory B-cell: 0.5 nTPM
T-reg: 0.5 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 6.6 nTPM
hypothalamus: 6 nTPM
white matter: 6 nTPM
basal ganglia: 5.1 nTPM
cerebral cortex: 5 nTPM
midbrain: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB5 as an antibody target. Whether an autoantibody or antibody against EFCAB5 could matter depends on whether native EFCAB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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