Seroatlas · Human Serome Atlas

EFCAB3

EF-hand calcium-binding domain-containing protein 3

Also known as: EFCB3_HUMAN, FLJ25818

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7B9
Gene: EFCAB3
Ensembl: ENSG00000172421
Chromosome: 17
Canonical length: 438 aa
Protein class: Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q8N7B9|EFCAB3
     1  MAVSEIKPKL KLNPLTKVPI SHNKRDRDLP GSLQCQLQHK EKKLSASQMA AFQDAYNFFY
    61  KDKTGCIDFH GLMCTVAKLG MNLTKHDVYN ELKCADIDRD GKVNFSDFIK VLTDKNLFLK
   121  AVVPEKETCL DLAGNPGILL FEILSRLLET SALPRKSIIE IVSYFQRKFQ HTGPGMLWSP
   181  YTMGYGKRTL KPDICTPPSS SMAAFANAAR IAIMKEKDLF KFLEELKRCN SGSDSPYSKI
   241  PIFPLFPNVD GVVMGKPFKD MQKLEMLRIK EPLHFFEDYF FHKRDWKTQA ANIKSMDPAS
   301  GYSNNIFTID QMLKKKQTCT VADATAIKQH VKRATDTYNL GIALEHRKEM LNLWQKIRGD
   361  LIGMDSRNES FYDTFSTYTW SWNVCQELLS PKDLRLYDAY VNRNSSHNSR SSSSSDTSEC
   421  YTDSGRKRKR KGLKGFQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

testis: 5.5 nTPM
adipose tissue: 0.4 nTPM
retina: 0.2 nTPM
esophagus: 0.1 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

early spermatids: 139 nCPM
late primary spermatocytes: 31 nCPM
late spermatids: 9.6 nCPM
papillary tip epithelial cells: 7.7 nCPM
undifferentiated spermatogonia: 4 nCPM
podocytes: 3.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.4 nTPM
cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB3 as an antibody target. Whether an autoantibody or antibody against EFCAB3 could matter depends on whether native EFCAB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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