Seroatlas · Human Serome Atlas

EFCAB13

EF-hand calcium-binding domain-containing protein 13

Also known as: C17orf57, EFC13_HUMAN, FLJ40342

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY85
Gene: EFCAB13
Ensembl: ENSG00000178852
Chromosome: 17
Canonical length: 973 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

No narrative summary is available for EFCAB13 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

973 residues, UniProt reviewed canonical sequence.

>Q8IY85|EFCAB13
     1  METKVHLFCQ AEENIDLLDD GSNSFATDLS SGTINHKKYI KFSKTIEKEI SPEIRSLSPE
    61  YKKIFETSII FCGEEKSSDF SGEKKVGRKS LQVQQHSKRT EIIPPFLKLS KEKVTRKENS
   121  LCKLPNQYSV HKTSSPLCTS SAITREKEML SNLYMTLYDE VTHGYLHSKE LSALHKACKI
   181  FSKIRSGKIY VNDLPVILCI LRISISDLEM RQALKTVDID AFQDALKIFC RIKGGRVSTD
   241  DVFAVLDSMG IPINREILEE VTKHTYIDSN HMVDIGDIIF TLNELQEQYE DVSITEGSPL
   301  NEITSDRKLS SVAGCYLKYK KKNSLSSKLP EPSISKKLNK KSNQYYSKIM ENDDLESKRP
   361  KNTWQIRKFL GGVGSSNVGV QEPYSKNGIN FKKHSEKGEI HDSKSKPQSL KSSTSLSKSL
   421  DKSDISSIPK LQKPAVRKHS SLQKQVSSTE KTAISTLENF CEAISKLQEN YIAAEELQSI
   481  LPSTGINLLD EEFQKIVTDT SRNENGMVEL DDFVNALAKE RSFPECNALP GVIKAIDKIK
   541  DKNVDYEDLN TCLQNFGIYL SKPEFKKITE LTEAGETKKV NFKEFIDTMM SNTECFSEKL
   601  VLPDAIETLD DLRKETMSVS DLWNTLSSLN SNLKKDEFLA ALELVTVDEG DKVQFEEFAK
   661  VVRNMRDAAR LEELQEVVLA ADLLEGDMIA GKNLEDFLRN VGIKSPKEEV EKILQSDFVS
   721  EDNMVNIKDC MRALRDTQKF SNYIDFRKEA SNLKLPKVNE IKEAANILSH VDNGKIGIPD
   781  LEHALKCLNV NLTEEDFNEA LNCCNVSDNM EVDLKDFLMK MKESPHFQKS KATQILLATT
   841  QILQNDLVDV SDLKTLLMDK DLHTANAILT VMLRHVPEHE SGKVSIQEFM TKLSDILTIP
   901  KAAGKFYLIC TYCPDLERQA VVYMLKTIQD SIVKAQVSKK QYNMNIKQHK ISLHNFCLNS
   961  KANIAKLNPN SKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
thyroid gland: 13 nTPM
endometrium: 5.5 nTPM
kidney: 5 nTPM
blood vessel: 4.5 nTPM
duodenum: 4.5 nTPM

Single-cell type

epicardial cells: 348 nCPM
late spermatids: 278 nCPM
podocytes: 269 nCPM
early spermatids: 247 nCPM
early primary spermatocytes: 193 nCPM
cardiomyocytes: 174 nCPM

Immune cell

basophil: 2.9 nTPM
naive B-cell: 2.7 nTPM
memory B-cell: 2.2 nTPM
naive CD4 T-cell: 1.2 nTPM
classical monocyte: 1 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

white matter: 16 nTPM
cerebellum: 15 nTPM
medulla oblongata: 15 nTPM
hypothalamus: 14 nTPM
pons: 14 nTPM
thalamus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EFCAB13.

Disease | ImmuneIEDB

Conditions an epitope on EFCAB13 was assayed in.

human immunodeficiency virus infectious disease T cell
collecting duct carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 1
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

EF-hand domain pair

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB13 as an antibody target. Whether an autoantibody or antibody against EFCAB13 could matter depends on whether native EFCAB13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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