Seroatlas · Human Serome Atlas

EFCAB12

EF-hand calcium-binding domain-containing protein 12

Also known as: C3orf25, EFC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NXP0
Gene: EFCAB12
Ensembl: ENSG00000172771
Chromosome: 3
Canonical length: 572 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Midbody ring

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q6NXP0|EFCAB12
     1  MDDDYEAYHS LFLSLLGLCP SKTPINENAP VFDPEPVIAH CFKQFQQKDF RLPQTRRRII
    61  MVPRKEDQTP LNPASQPQAP PKPIPSFKVL EARDIQEQPE DRKTWLSQRS KLRQELESFG
   121  DVKRWLENKP SITPSEAKVL HMIHEEQSAQ PNASQATTRT TRKKAPRLSR LSRQMVPQLQ
   181  LPEPPALSVM YSYLHSRKIK ILEIFHKVGQ GENQRITREE FIAAVKAVGV PLKNQEVEDI
   241  VIYLSSLGKH NTITMDILAN TYKQWSMAQQ RSSLATAREH YILAKHRDSL KGPLKKQEVD
   301  SAPQLPKVDL LTVPAVDTQM ETRPMTLEEM EEVGKRYRER QRQHKLTIPS IQYTEQCHLV
   361  RCGNRHFDEH CLPSTIHGDM RELIDSARRH NFLVYLQCWK LCKSYGLPLT EDILMKALLY
   421  PGDKIIFQMD KVCPIRQPGG YYSDWKVFSP NLALLRSQGP GKSKRTDKKT PKKSKKMRFK
   481  EFEEFTRKLK VKRSSGLQQT HPNSFWPGHL LDKLQLYLPT VATDRSLALF SCVQHQPHVY
   541  PATYHPDHWW PLRNKNYMTH AHYDAAKVYY IN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 19 nTPM
choroid plexus: 10 nTPM
testis: 6.6 nTPM
pituitary gland: 3.4 nTPM
hypothalamus: 2.9 nTPM
prostate: 2.9 nTPM

Single-cell type

ependymal cells: 131 nCPM
respiratory ciliated cells: 92 nCPM
fallopian tube ciliated cells: 72 nCPM
endometrial ciliated cells: 61 nCPM
choroid plexus epithelial cells: 52 nCPM
early spermatids: 41 nCPM

Immune cell

eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 28 nTPM
midbrain: 16 nTPM
medulla oblongata: 12 nTPM
spinal cord: 8.3 nTPM
hypothalamus: 5.9 nTPM
pons: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Protein domainsUniProt · Pfam · InterPro

EF-hand domain
EF-hand domain pair
EF-hand calcium-binding domain-containing protein 12

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB12 as an antibody target. Whether an autoantibody or antibody against EFCAB12 could matter depends on whether native EFCAB12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...