Seroatlas · Human Serome Atlas

EFCAB11

EF-hand calcium-binding domain-containing protein 11

Also known as: C14orf143, EFC11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUY7
Gene: EFCAB11
Ensembl: ENSG00000140025
Chromosome: 14
Canonical length: 163 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions,Cytosol

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q9BUY7|EFCAB11
     1  MFFSEARARS RTWEASPSEH RKWVEVFKAC DEDHKGYLSR EDFKTAVVML FGYKPSKIEV
    61  DSVMSSINPN TSGILLEGFL NIVRKKKEAQ RYRNEVRHIF TAFDTYYRGF LTLEDFKKAF
   121  RQVAPKLPER TVLEVFREVD RDSDGHVSFR DFEYALNYGQ KEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
fallopian tube: 10 nTPM
breast: 8.5 nTPM
parathyroid gland: 7.7 nTPM
amygdala: 7.4 nTPM
thyroid gland: 7.3 nTPM

Single-cell type

early spermatids: 486 nCPM
late spermatids: 367 nCPM
late primary spermatocytes: 282 nCPM
proximal tubule cells: 49 nCPM
renal collecting duct principal cells: 46 nCPM
renal connecting tubule cells: 45 nCPM

Immune cell

basophil: 15 nTPM
non-classical monocyte: 5 nTPM
eosinophil: 3 nTPM
NK-cell: 2.8 nTPM
neutrophil: 2.6 nTPM
intermediate monocyte: 2.5 nTPM

Brain region

choroid plexus: 13 nTPM
amygdala: 11 nTPM
midbrain: 11 nTPM
white matter: 11 nTPM
medulla oblongata: 11 nTPM
basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule cytoskeleton organization

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB11 as an antibody target. Whether an autoantibody or antibody against EFCAB11 could matter depends on whether native EFCAB11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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