Seroatlas · Human Serome Atlas

EFCAB10

EF-hand calcium-binding domain-containing protein 10

Also known as: EFC10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFE3
Gene: EFCAB10
Ensembl: ENSG00000185055
Chromosome: 7
Canonical length: 127 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>A6NFE3|EFCAB10
     1  METSSRELQA AEYLEKHQIK EVVSYLTSAL LFFRPEKPKE YLISLLERLR IAKVTGVAFP
    61  FFMDNSNIVA MFEMMDSSGR GTISFVQYKE ALKTLGLCTE DEDLQDDGHK ITLDKFKEEV
   121  NKRMKEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EFCAB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 28 nTPM
testis: 22 nTPM
choroid plexus: 12 nTPM
hypothalamus: 3.4 nTPM
basal ganglia: 3.3 nTPM
lung: 3 nTPM

Single-cell type

oocytes: 530 nCPM
late primary spermatocytes: 280 nCPM
respiratory ciliated cells: 236 nCPM
early spermatids: 230 nCPM
fallopian tube ciliated cells: 202 nCPM
endometrial ciliated cells: 155 nCPM

Immune cell

basophil: 1 nTPM
naive B-cell: 0.6 nTPM
naive CD4 T-cell: 0.6 nTPM
gdT-cell: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM

Brain region

choroid plexus: 31 nTPM
midbrain: 22 nTPM
medulla oblongata: 19 nTPM
spinal cord: 15 nTPM
hypothalamus: 13 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0.01
gnomAD missense Z: 0.44

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Protein domainsUniProt · Pfam · InterPro

EF-hand domain
EF-hand domain pair
EF-hand calcium-binding domain-containing protein 10
EF-hand calcium-binding domain-containing protein 10, dimerization/docking domain
EFCAB10, C-terminal EF-hand
EFCAB10, C-terminal EF-hand

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EFCAB10 as an antibody target. Whether an autoantibody or antibody against EFCAB10 could matter depends on whether native EFCAB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EFCAB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EFCAB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...