EEIG2
EEIG family member 2
Also known as: DKFZp779B126, EEIG2_HUMAN, FAM102B, SYM-3B
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T8I3
- Gene
- EEIG2
- Ensembl
- ENSG00000162636
- Chromosome
- 1
- Canonical length
- 360 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Cytosol
OverviewNCBI Gene
No narrative summary is available for EEIG2 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
360 residues, UniProt reviewed canonical sequence.
>Q5T8I3|EEIG2
1 MMKKKKFKFK VDFELEELSS VPFVNGVLFC KMRLLDGGSF TAESSREVVQ ANCVRWRKKF
61 SFMCKMSASA ATGILDPCIY RVSVRKELKG GKAYAKLGFA DLNLAEFAGS GNTTRRCLLE
121 GYDTKNTRQD NSILKVLISM QLMSGDPCFK TPPSTSMSIP IAGESESLQE DRKGGETLKV
181 HLGIADLSAK SASVPDELGA CGHSRTSSYA SQQSKVSGYS TCHSRSSSFS ELCHRRNTSV
241 GSTSTGVESI LEPCDEIEQK IAEPNLDTAD KEDTASEKLS RCPVKQDSVE SQLKRVDDTR
301 VDADDIVEKI LQSQDFSLDS SAEEEGLRLF VGPGGSTTFG SHHLPNRVGS GAYEQVVIKRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against EEIG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 20 nTPM
- cerebral cortex: 16 nTPM
- urinary bladder: 15 nTPM
- gallbladder: 14 nTPM
- rectum: 14 nTPM
- salivary gland: 13 nTPM
Single-cell type
- monocytes: 252 nCPM
- neutrophil progenitors: 249 nCPM
- microglia: 190 nCPM
- macrophages: 176 nCPM
- cdc: 159 nCPM
- mast cells: 158 nCPM
Immune cell
- basophil: 2.9 nTPM
- myeloid DC: 1 nTPM
- intermediate monocyte: 0.9 nTPM
- classical monocyte: 0.4 nTPM
- eosinophil: 0.4 nTPM
- memory CD8 T-cell: 0.4 nTPM
Brain region
- cerebral cortex: 28 nTPM
- hypothalamus: 26 nTPM
- basal ganglia: 25 nTPM
- pons: 25 nTPM
- midbrain: 22 nTPM
- thalamus: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.77
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EEIG2 as an antibody target. Whether an autoantibody or antibody against EEIG2 could matter depends on whether native EEIG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EEIG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EEIG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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