Seroatlas · Human Serome Atlas

EEIG1

Early estrogen-induced gene 1 protein

Also known as: bA203J24.7, C9orf132, EEIG1_HUMAN, FAM102A, SYM-3A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T9C2
Gene: EEIG1
Ensembl: ENSG00000167106
Chromosome: 9
Canonical length: 384 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of osteoclast differentiation. Predicted to be located in cytoplasm; membrane raft; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>Q5T9C2|EEIG1
     1  MAFLMKKKKF KFQTTFTLEE LTAVPFVNGV LFCKVRLLDG GDFVSLSSRE EVQENCVRWR
    61  KRFTFVCKMS ANPATGLLDP CVFRVSVRKE LKGGKAYSKL GFADLNLAEF AGSGSTVRCC
   121  LLEGYDTKNT RQDNSILKVT IGMFLLSGDP CFKTPPSTAK SISIPGQDSS LQLTCKGGGT
   181  SSGGSSTNSL TGSRPPKARP TILSSGLPEE PDQNLSSPEE VFHSGHSRNS SYASQQSKIS
   241  GYSTEHSRSS SLSDLTHRRN TSTSSSASGG LGMTVEGPEG SEREHRPPEK PPRPPRPLHL
   301  SDRSFRRKKD SVESHPTWVD DTRIDADAIV EKIVQSQDFT DGSNTEDSNL RLFVSRDGSA
   361  TLSGIQLATR VSSGVYEPVV IESH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEIG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

stomach: 100 nTPM
spinal cord: 78 nTPM
basal ganglia: 69 nTPM
small intestine: 62 nTPM
hippocampal formation: 60 nTPM
esophagus: 58 nTPM

Single-cell type

foveolar cells: 440 nCPM
esophageal apical cells: 283 nCPM
enterocytes: 242 nCPM
conjunctival goblet cells: 203 nCPM
renal collecting duct principal cells: 182 nCPM
pancreatic acinar cells: 165 nCPM

Immune cell

T-reg: 13 nTPM
memory CD4 T-cell: 9.7 nTPM
naive CD4 T-cell: 8.9 nTPM
naive CD8 T-cell: 6.3 nTPM
MAIT T-cell: 6.1 nTPM
memory CD8 T-cell: 5.7 nTPM

Brain region

white matter: 277 nTPM
thalamus: 176 nTPM
basal ganglia: 167 nTPM
cerebral cortex: 154 nTPM
midbrain: 153 nTPM
medulla oblongata: 147 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.11
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of osteoclast differentiation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EEIG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRDM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EEIG1 as an antibody target. Whether an autoantibody or antibody against EEIG1 could matter depends on whether native EEIG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EEIG1 is annotated at the cell surface, where native EEIG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EEIG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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