Seroatlas · Human Serome Atlas

EEF1E1

Eukaryotic translation elongation factor 1 epsilon-1

Also known as: AIMP3, MCA3_HUMAN, P18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43324
Gene: EEF1E1
Ensembl: ENSG00000124802
Chromosome: 6
Canonical length: 174 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>O43324|EEF1E1
     1  MAAAAELSLL EKSLGLSKGN KYSAQGERQI PVLQTNNGPS LTGLTTIAAH LVKQANKEYL
    61  LGSTAEEKAI VQQWLEYRVT QVDGHSSKND IHTLLKDLNS YLEDKVYLTG YNFTLADILL
   121  YYGLHRFIVD LTVQEKEKYL NVSRWFCHIQ HYPGIRQHLS SVVFIKNRLY TNSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEF1E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 54 nTPM
testis: 54 nTPM
kidney: 42 nTPM
hypothalamus: 35 nTPM
lymph node: 30 nTPM
parathyroid gland: 29 nTPM

Single-cell type

late spermatids: 222 nCPM
early spermatids: 212 nCPM
late primary spermatocytes: 51 nCPM
gastric chief cells: 35 nCPM
parietal cells: 30 nCPM
gastric progenitor cells: 13 nCPM

Immune cell

myeloid DC: 61 nTPM
naive B-cell: 47 nTPM
T-reg: 46 nTPM
memory B-cell: 43 nTPM
naive CD8 T-cell: 40 nTPM
naive CD4 T-cell: 38 nTPM

Brain region

midbrain: 55 nTPM
cerebellum: 52 nTPM
hypothalamus: 49 nTPM
pons: 49 nTPM
medulla oblongata: 46 nTPM
cerebral cortex: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.08
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glutathione S-transferase, C-terminal-like
Glutathione S-transferase, C-terminal domain superfamily
Nuclear-export cofactor Arc1-like, N-terminal domain
Nuclear-export cofactor Arc1p
Eukaryotic translation elongation factor 1 epsilon-1
AIMP3/p18, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EEF1E1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EEF1E1 as an antibody target. Whether an autoantibody or antibody against EEF1E1 could matter depends on whether native EEF1E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EEF1E1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EEF1E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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