EEF1AKMT4-ECE2
EEF1AKMT4-ECE2 readthrough transcript protein
Also known as: EFCE2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DPD8
- Gene
- EEF1AKMT4-ECE2
- Ensembl
- ENSG00000284917
- Chromosome
- 3
- Canonical length
- 883 aa
- Protein class
- Enzymes, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene represents naturally occurring readthrough transcription between adjacent genes eukaryotic translation elongation factor 1 alpha lysine methyltransferase 4 (GeneID: 110599564) and endothelin converting enzyme 2 (GeneID:9718). The readthrough transcript representing this gene encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]
Canonical amino-acid sequenceUniProt
883 residues, UniProt reviewed canonical sequence.
>P0DPD8|EEF1AKMT4-ECE2
1 MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED
61 RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP
121 SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VGFQKGTRQL LGSRTQLELV
181 LAGASLLLAA LLLGCLVALG VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ
241 FSCGGWIRRN PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL
301 QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF FTVYISADSK
361 SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME ELGMLLGGRP TSTREQMQQV
421 LELEIQLANI TVPQDQRRDE EKIYHKMSIS ELQALAPSMD WLEFLSFLLS PLELSDSEPV
481 VVYGMDYLQQ VSELINRTEP SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS
541 CVPRWQTCIS NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE
601 KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL YNFSAKVMAD
661 QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF YARNHPKALN FGGIGVVMGH
721 ELTHAFDDQG REYDKEGNLR PWWQNESLAA FRNHTACMEE QYNQYQVNGE RLNGRQTLGE
781 NIADNGGLKA AYNAYKAWLR KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL
841 VTDPHSPARF RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against EEF1AKMT4-ECE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 0.5 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 0.5 nTPM
- appendix: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- adipose tissue: 0 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 52 nCPM
- early spermatids: 20 nCPM
- somatotrophs: 7.2 nCPM
- retinal amacrine cells: 6.5 nCPM
- epicardial cells: 4.5 nCPM
- lactotrophs: 4.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
OntologyGO
Biological processes
- brain development
- cardioblast differentiation
- heart development
- methylation
- peptide hormone processing
- protein processing
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Peptidase M13
- Peptidase M13, N-terminal domain
- Peptidase M13, C-terminal domain
- Metallopeptidase, catalytic domain superfamily
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- Methyltransferase domain 25
- Peptidase M13, domain 2
- Peptidase family M13
- Peptidase family M13
- Methyltransferase domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EEF1AKMT4-ECE2 as an antibody target. Whether an autoantibody or antibody against EEF1AKMT4-ECE2 could matter depends on whether native EEF1AKMT4-ECE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EEF1AKMT4-ECE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EEF1AKMT4-ECE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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