Seroatlas · Human Serome Atlas

EEF1AKMT4

EEF1A lysine methyltransferase 4

Also known as: EFMT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPD7
Gene: EEF1AKMT4
Ensembl: ENSG00000284753
Chromosome: 3
Canonical length: 255 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the lysine-specific methyltransferase (KMT) family. The encoded enzyme catalyzes the methylation of lysine-36 of the eukaryotic translation elongation factor 1 alpha. Methylation by this enzyme may affect endoplasmic reticulum-related processes. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>P0DPD7|EEF1AKMT4
     1  MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED
    61  RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP
   121  SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VSRVLVPGGR FISMTSAAPH
   181  FRTRHYAQAY YGWSLRHATY GSGFHFHLYL MHKGGKLSVA QLALGAQILS PPRPPTSPCF
   241  LQDSDHEDFL SAIQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEF1AKMT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

liver: 23 nTPM
testis: 23 nTPM
pancreas: 15 nTPM
skeletal muscle: 12 nTPM
esophagus: 11 nTPM
skin: 8.1 nTPM

Single-cell type

suprabasal keratinocytes: 5 nCPM
late primary spermatocytes: 4.7 nCPM
late spermatids: 4.5 nCPM
other brain neurons: 4 nCPM
basal keratinocytes: 3.5 nCPM
early spermatids: 2.6 nCPM

Immune cell

classical monocyte: 23 nTPM
myeloid DC: 20 nTPM
intermediate monocyte: 19 nTPM
plasmacytoid DC: 18 nTPM
T-reg: 16 nTPM
non-classical monocyte: 13 nTPM

Brain region

cerebellum: 7.4 nTPM
hypothalamus: 2.9 nTPM
cerebral cortex: 2.7 nTPM
medulla oblongata: 2.4 nTPM
pons: 2.1 nTPM
choroid plexus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.06
DepMap dependency class: none

OntologyGO

Biological processes

methylation

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EEF1AKMT4 as an antibody target. Whether an autoantibody or antibody against EEF1AKMT4 could matter depends on whether native EEF1AKMT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EEF1AKMT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EEF1AKMT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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