Seroatlas · Human Serome Atlas

EEF1AKMT3

EEF1A lysine methyltransferase 3

Also known as: DKFZP586D0919, EFMT3_HUMAN, FAM119B, METTL21B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AZ1
Gene: EEF1AKMT3
Ensembl: ENSG00000123427
Chromosome: 12
Canonical length: 226 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitotic chromosome,Centrosome

OverviewNCBI Gene

Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Located in several cellular components, including centrosome; chromosome; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q96AZ1|EEF1AKMT3
     1  MADPGPDPES ESESVFPREV GLFADSYSEK SQFCFCGHVL TITQNFGSRL GVAARVWDAA
    61  LSLCNYFESQ NVDFRGKKVI ELGAGTGIVG ILAALQGGDV TITDLPLALE QIQGNVQANV
   121  PAGGQAQVRA LSWGIDHHVF PANYDLVLGA DIVYLEPTFP LLLGTLQHLC RPHGTIYLAS
   181  KMRKEHGTES FFQHLLPQHF QLELAQRDED ENVNIYRARH REPRPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEF1AKMT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

pancreas: 21 nTPM
salivary gland: 18 nTPM
kidney: 11 nTPM
ovary: 10 nTPM
cervix: 9.9 nTPM
thyroid gland: 9.4 nTPM

Single-cell type

epicardial cells: 27 nCPM
late spermatids: 23 nCPM
early spermatids: 12 nCPM
cardiomyocytes: 6.2 nCPM
adipocytes: 1.7 nCPM
basal prostatic cells: 1.2 nCPM

Immune cell

MAIT T-cell: 7.8 nTPM
non-classical monocyte: 4.7 nTPM
memory CD4 T-cell: 3.5 nTPM
myeloid DC: 3.1 nTPM
classical monocyte: 3 nTPM
total PBMC: 2.3 nTPM

Brain region

cerebellum: 9.8 nTPM
medulla oblongata: 8.6 nTPM
white matter: 8.6 nTPM
choroid plexus: 8.3 nTPM
pons: 8.1 nTPM
midbrain: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

peptidyl-lysine methylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EEF1AKMT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EEF1AKMT3 as an antibody target. Whether an autoantibody or antibody against EEF1AKMT3 could matter depends on whether native EEF1AKMT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EEF1AKMT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EEF1AKMT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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