Seroatlas · Human Serome Atlas

EEF1AKMT2

EEF1A lysine methyltransferase 2

Also known as: C10orf138, Efm4, EFMT2_HUMAN, METTL10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JPI9
Gene: EEF1AKMT2
Ensembl: ENSG00000203791
Chromosome: 10
Canonical length: 236 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q5JPI9|EEF1AKMT2
     1  MSSGADGGGG AAVAARSDKG SPGEDGFVPS ALGTREHWDA VYERELQTFR EYGDTGEIWF
    61  GEESMNRLIR WMQKHKIPLD ASVLDIGTGN GVFLVELAKF GFSNITGIDY SPSAIQLSGS
   121  IIEKEGLSNI KLKVEDFLNL STQLSGFHIC IDKGTFDAIS LNPDNAIEKR KQYVKSLSRV
   181  LKVKGFFLIT SCNWTKEELL NEFSEGFELL EELPTPKFSF GGRSGNSVAA LVFQKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEF1AKMT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

ovary: 5.2 nTPM
cerebellum: 5.1 nTPM
basal ganglia: 5 nTPM
breast: 4.9 nTPM
liver: 4.9 nTPM
skin: 4.7 nTPM

Single-cell type

late primary spermatocytes: 35 nCPM
early primary spermatocytes: 13 nCPM
thyrotrophs: 7 nCPM
corticotrophs: 6.5 nCPM
erythrocyte progenitors: 6.1 nCPM
pituitary stem cells: 5 nCPM

Immune cell

NK-cell: 4.5 nTPM
MAIT T-cell: 2.5 nTPM
naive CD4 T-cell: 2.2 nTPM
memory CD8 T-cell: 2 nTPM
memory B-cell: 1.9 nTPM
T-reg: 1.9 nTPM

Brain region

cerebellum: 7.4 nTPM
white matter: 5.1 nTPM
cerebral cortex: 4.9 nTPM
basal ganglia: 4.4 nTPM
midbrain: 4 nTPM
amygdala: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

peptidyl-lysine methylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Methyltransferase domain
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Methyltransferase domain
Protein-lysine N-methyltransferase Efm4/METTL10

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EEF1AKMT2 as an antibody target. Whether an autoantibody or antibody against EEF1AKMT2 could matter depends on whether native EEF1AKMT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EEF1AKMT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EEF1AKMT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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