Seroatlas · Human Serome Atlas

EDN2

Endothelin-2

Also known as: EDN2_HUMAN, ET2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20800
Gene
EDN2
Ensembl
ENSG00000127129
Chromosome
1
Canonical length
178 aa
Protein class
Predicted secreted proteins
Subcellular location
Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>P20800|EDN2
     1  MVSVPTTWCS VALALLVALH EGKGQAAATL EQPASSSHAQ GTHLRLRRCS CSSWLDKECV
    61  YFCHLDIIWV NTPEQTAPYG LGNPPRRRRR SLPRRCQCSS ARDPACATFC LRRPWTEAGA
   121  VPSRKSPADV FQTGKTGATT GELLQRLRDI STVKSLFAKR QQEAMREPRS THSRWRKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EDN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • vagina: 32 nTPM
  • cervix: 30 nTPM
  • esophagus: 20 nTPM
  • small intestine: 17 nTPM
  • skin: 15 nTPM
  • kidney: 7.3 nTPM

Single-cell type

  • conjunctival goblet cells: 421 nCPM
  • esophageal apical cells: 377 nCPM
  • prostatic club cells: 175 nCPM
  • prostatic hillock cells: 153 nCPM
  • enterocytes: 94 nCPM
  • basal prostatic cells: 85 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 2.2 nTPM
  • hippocampal formation: 0.3 nTPM
  • medulla oblongata: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • pons: 0.2 nTPM
  • white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0.06
gnomAD missense Z
0.13
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EDN2 as an antibody target. Whether an autoantibody or antibody against EDN2 could matter depends on whether native EDN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EDN2 is annotated as secreted, so native EDN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EDN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EDN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...