Seroatlas · Human Serome Atlas

EDEM2

ER degradation-enhancing alpha-mannosidase-like protein 2

Also known as: bA4204.1, C20orf31, C20orf49, EDEM2_HUMAN, FLJ10783

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BV94
Gene
EDEM2
Ensembl
ENSG00000088298
Chromosome
20
Canonical length
578 aa
Protein class
Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This record represents naturally-occurring readthrough transcription between upstream GeneID:101410538 (MMP24 antisense RNA 1) and the ER degradation enhancing alpha-mannosidase like protein 2 (EDEM2) gene. Readthrough transcripts may encode proteins similar to those encoded by the EDEM2 gene. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q9BV94|EDEM2
     1  MPFRLLIPLG LLCALLPQHH GAPGPDGSAP DPAHYRERVK AMFYHAYDSY LENAFPFDEL
    61  RPLTCDGHDT WGSFSLTLID ALDTLLILGN VSEFQRVVEV LQDSVDFDID VNASVFETNI
   121  RVVGGLLSAH LLSKKAGVEV EAGWPCSGPL LRMAEEAARK LLPAFQTPTG MPYGTVNLLH
   181  GVNPGETPVT CTAGIGTFIV EFATLSSLTG DPVFEDVARV ALMRLWESRS DIGLVGNHID
   241  VLTGKWVAQD AGIGAGVDSY FEYLVKGAIL LQDKKLMAMF LEYNKAIRNY TRFDDWYLWV
   301  QMYKGTVSMP VFQSLEAYWP GLQSLIGDID NAMRTFLNYY TVWKQFGGLP EFYNIPQGYT
   361  VEKREGYPLR PELIESAMYL YRATGDPTLL ELGRDAVESI EKISKVECGF ATIKDLRDHK
   421  LDNRMESFFL AETVKYLYLL FDPTNFIHNN GSTFDAVITP YGECILGAGG YIFNTEAHPI
   481  DPAALHCCQR LKEEQWEVED LMREFYSLKR SRSKFQKNTV SSGPWEPPAR PGTLFSPENH
   541  DQARERKPAK QKVPLLSCPS QPFTSKLALL GQVFLDSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EDEM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 42 nTPM
  • liver: 37 nTPM
  • pancreas: 32 nTPM
  • spleen: 32 nTPM
  • placenta: 26 nTPM
  • bone marrow: 26 nTPM

Single-cell type

  • extravillous trophoblasts: 212 nCPM
  • syncytiotrophoblasts: 116 nCPM
  • plasma cells: 95 nCPM
  • cytotrophoblasts: 86 nCPM
  • hofbauer cells: 84 nCPM
  • migrating cytotrophoblasts: 82 nCPM

Immune cell

  • myeloid DC: 101 nTPM
  • classical monocyte: 97 nTPM
  • total PBMC: 80 nTPM
  • MAIT T-cell: 79 nTPM
  • eosinophil: 76 nTPM
  • non-classical monocyte: 73 nTPM

Brain region

  • cerebellum: 23 nTPM
  • thalamus: 22 nTPM
  • choroid plexus: 18 nTPM
  • medulla oblongata: 18 nTPM
  • pons: 17 nTPM
  • white matter: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
1.54
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EDEM2 as an antibody target. Whether an autoantibody or antibody against EDEM2 could matter depends on whether native EDEM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EDEM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EDEM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EDEM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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