Seroatlas · Human Serome Atlas

EDDM13

Epididymal protein 13

Also known as: EDD13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTR0
Gene
EDDM13
Ensembl
ENSG00000267710
Chromosome
19
Canonical length
161 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be located in extracellular region and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>A0A1B0GTR0|EDDM13
     1  MHRSEPFLKM SLLILLFLGL AEACTPREVA TKEKINLLKG IIGLMSRLSP DGLRHNITSL
    61  KMPPLVSPQD RTEEEIKKIL GLLSLQVLHE ETSGCKEEVK PFSGTTPSRK PLPKRKNTWN
   121  FLKCAYMVMT YLFVSYNKGD WCYCHYCNLE LDIRDDPCCS F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EDDM13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 93 nTPM
  • retina: 0.6 nTPM
  • skin: 0.4 nTPM
  • thyroid gland: 0.2 nTPM
  • lymph node: 0.1 nTPM
  • pancreas: 0.1 nTPM

Single-cell type

  • epididymal principal cells: 1,799 nCPM
  • epicardial cells: 196 nCPM
  • cardiomyocytes: 179 nCPM
  • adipocytes: 40 nCPM
  • fibro-adipogenic progenitors: 36 nCPM
  • rod photoreceptor cells: 33 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 6.7 nTPM
  • basal ganglia: 4.3 nTPM
  • cerebral cortex: 4 nTPM
  • hippocampal formation: 3.7 nTPM
  • amygdala: 3.5 nTPM
  • midbrain: 3.5 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EDDM13 as an antibody target. Whether an autoantibody or antibody against EDDM13 could matter depends on whether native EDDM13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EDDM13 is annotated as secreted, so native EDDM13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EDDM13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EDDM13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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