Seroatlas · Human Serome Atlas

ECSCR

Endothelial cell-specific chemotaxis regulator

Also known as: ARIA, ECSCR_HUMAN, ECSM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q19T08
Gene: ECSCR
Ensembl: ENSG00000249751
Chromosome: 5
Canonical length: 205 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q19T08|ECSCR
     1  MGTAGAMQLC WVILGFLLFR GHNSQPTMTQ TSSSQGGLGG LSLTTEPVSS NPGYIPSSEA
    61  NRPSHLSSTG TPGAGVPSSG RDGGTSRDTF QTVPPNSTTM SLSMREDATI LPSPTSETVL
   121  TVAAFGVISF IVILVVVVII LVGVVSLRFK CRKSKESEDP QKPGSSGLSE SCSTANGEKD
   181  SITLISMKNI NMNNGKQSLS AEKVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ECSCR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 61 nTPM
lung: 58 nTPM
breast: 58 nTPM
heart muscle: 55 nTPM
thyroid gland: 40 nTPM
blood vessel: 39 nTPM

Single-cell type

vascular endothelial cells: 9.4 nCPM
lymphatic endothelial cells: 4.8 nCPM
gastric chief cells: 1.1 nCPM
innate lymphoid cells: 0.4 nCPM
pericytes: 0.2 nCPM
cardiomyocytes: 0.1 nCPM

Immune cell

gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

thalamus: 5.7 nTPM
pons: 5 nTPM
medulla oblongata: 4.4 nTPM
spinal cord: 4.4 nTPM
cerebral cortex: 4.3 nTPM
hypothalamus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.77

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Endothelial cell-specific chemotaxis regulator
Endothelial cell-specific chemotaxis regulator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ECSCR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FLNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ECSCR as an antibody target. Whether an autoantibody or antibody against ECSCR could matter depends on whether native ECSCR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ECSCR is annotated at the cell surface, where native ECSCR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ECSCR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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