Seroatlas · Human Serome Atlas

ECRG4

Augurin

Also known as: AUGN_HUMAN, augurin, C2orf40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1Z8
Gene: ECRG4
Ensembl: ENSG00000119147
Chromosome: 2
Canonical length: 148 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway; positive regulation of hormone secretion; and vasopressin secretion. Located in apical plasma membrane; dense core granule; and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q9H1Z8|ECRG4
     1  MAASPARPAV LALTGLALLL LLCWGPGGIS GNKLKLMLQK REAPVPTKTK VAVDENKAKE
    61  FLGSLKRQKR QLWDRTRPEV QQWYQQFLYM GFDEAKFEDD ITYWLNRDRN GHEYYGDYYQ
   121  RHYDEDSAIG PRSPYGFRHG ASVNYDDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ECRG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 412 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 412 nTPM
blood vessel: 180 nTPM
stomach: 164 nTPM
thyroid gland: 100 nTPM
seminal vesicle: 96 nTPM
pituitary gland: 95 nTPM

Single-cell type

early spermatids: 1,214 nCPM
breast myoepithelial cells: 885 nCPM
respiratory ciliated cells: 590 nCPM
pericytes: 419 nCPM
late primary spermatocytes: 239 nCPM
vascular smooth muscle cells: 239 nCPM

Immune cell

naive CD4 T-cell: 8.5 nTPM
naive CD8 T-cell: 7.2 nTPM
memory CD4 T-cell: 2 nTPM
total PBMC: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
T-reg: 0.8 nTPM

Brain region

choroid plexus: 467 nTPM
midbrain: 46 nTPM
spinal cord: 41 nTPM
medulla oblongata: 33 nTPM
hypothalamus: 27 nTPM
hippocampal formation: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Augurin
Oesophageal cancer-related gene 4

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ECRG4 as an antibody target. Whether an autoantibody or antibody against ECRG4 could matter depends on whether native ECRG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ECRG4 is annotated at the cell surface, where native ECRG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ECRG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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