Seroatlas · Human Serome Atlas

ECE2

Endothelin-converting enzyme 2

Also known as: ECE2_HUMAN, KIAA0604, MGC2408

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPD6
Gene: ECE2
Ensembl: ENSG00000145194
Chromosome: 3
Canonical length: 811 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Enables metalloendopeptidase activity. Involved in peptide hormone processing. Located in cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

811 residues, UniProt reviewed canonical sequence.

>P0DPD6|ECE2
     1  MNVALQELGA GSNMVEYKRA TLRDEDAPET PVEGGASPDA MEVGKGASPF SPGPSPGMTP
    61  GTPRSSGLFW RVTCPHLRSI SGLCSRTMVG FQKGTRQLLG SRTQLELVLA GASLLLAALL
   121  LGCLVALGVQ YHRDPSHSTC LTEACIRVAG KILESLDRGV SPCEDFYQFS CGGWIRRNPL
   181  PDGRSRWNTF NSLWDQNQAI LKHLLENTTF NSSSEAEQKT QRFYLSCLQV ERIEELGAQP
   241  LRDLIEKIGG WNITGPWDQD NFMEVLKAVA GTYRATPFFT VYISADSKSS NSNVIQVDQS
   301  GLFLPSRDYY LNRTANEKVL TAYLDYMEEL GMLLGGRPTS TREQMQQVLE LEIQLANITV
   361  PQDQRRDEEK IYHKMSISEL QALAPSMDWL EFLSFLLSPL ELSDSEPVVV YGMDYLQQVS
   421  ELINRTEPSI LNNYLIWNLV QKTTSSLDRR FESAQEKLLE TLYGTKKSCV PRWQTCISNT
   481  DDALGFALGS LFVKATFDRQ SKEIAEGMIS EIRTAFEEAL GQLVWMDEKT RQAAKEKADA
   541  IYDMIGFPDF ILEPKELDDV YDGYEISEDS FFQNMLNLYN FSAKVMADQL RKPPSRDQWS
   601  MTPQTVNAYY LPTKNEIVFP AGILQAPFYA RNHPKALNFG GIGVVMGHEL THAFDDQGRE
   661  YDKEGNLRPW WQNESLAAFR NHTACMEEQY NQYQVNGERL NGRQTLGENI ADNGGLKAAY
   721  NAYKAWLRKH GEEQQLPAVG LTNHQLFFVG FAQVWCSVRT PESSHEGLVT DPHSPARFRV
   781  LGTLSNSRDF LRHFGCPVGS PMNPGQLCEV W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ECE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 58 nTPM
cerebellum: 43 nTPM
basal ganglia: 39 nTPM
pancreas: 24 nTPM
midbrain: 24 nTPM
pituitary gland: 19 nTPM

Single-cell type

other brain neurons: 126 nCPM
brain inhibitory neurons: 93 nCPM
brain excitatory neurons: 47 nCPM
oligodendrocyte progenitor cells: 44 nCPM
bergmann glia: 20 nCPM
astrocytes: 17 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 106 nTPM
midbrain: 99 nTPM
pons: 62 nTPM
medulla oblongata: 48 nTPM
cerebral cortex: 45 nTPM
thalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ECE2 as an antibody target. Whether an autoantibody or antibody against ECE2 could matter depends on whether native ECE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ECE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ECE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...