EBLN2
Endogenous Bornavirus-like nucleoprotein 2
Also known as: EBLN2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P2I7
- Gene
- EBLN2
- Ensembl
- ENSG00000255423
- Chromosome
- 3
- Canonical length
- 272 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies
OverviewNCBI Gene
No narrative summary is available for EBLN2 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
272 residues, UniProt reviewed canonical sequence.
>Q6P2I7|EBLN2
1 MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH LRKDSQPSSP
61 GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI KDIKKAAKSM LDPAHKSHFH
121 PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN TVVGNENEER GTPYASRFKD MPNFIALEKS
181 SVLRHCCDLL IGIAAGSSDK ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI
241 GWISSRPWVG ELMFTLLFGD FESPLHKLRK SSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against EBLN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 15 nTPM
- ovary: 3.5 nTPM
- fallopian tube: 2.6 nTPM
- lung: 2.6 nTPM
- salivary gland: 2.6 nTPM
- retina: 2.5 nTPM
Single-cell type
- enterocytes: 0.1 nCPM
- microglia: 0.1 nCPM
- schwann cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- eosinophil: 3.3 nTPM
- T-reg: 1.9 nTPM
- naive CD8 T-cell: 1.7 nTPM
- gdT-cell: 1.6 nTPM
- neutrophil: 1.5 nTPM
- memory CD4 T-cell: 1.4 nTPM
Brain region
- white matter: 12 nTPM
- choroid plexus: 7.4 nTPM
- medulla oblongata: 7.4 nTPM
- basal ganglia: 6.9 nTPM
- pons: 6.7 nTPM
- cerebral cortex: 6.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.85
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EBLN2 as an antibody target. Whether an autoantibody or antibody against EBLN2 could matter depends on whether native EBLN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EBLN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EBLN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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